ArticleProceedings of the National Academy of Sciences of the United States of America2007
Up-regulation of heat shock proteins is essential for cold survival during insect diapause.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers.
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Who cites it
157 citing papers in PubMed, 540 citations in OpenAlex.
- Molecular characterization and seasonal, sex-associated expression patterns of HSP genes in Eurygaster integriceps (Hemiptera: Scutelleridae).Journal of insect science (Online) · 2026Article
- Differential resistance of heat shock proteins (HSP70 and HSP90) in Anopheles culicifacies mosquitoes with respect to variations in temperature in India.Molecular biology reports · 2026Article
- Transcriptomic and Proteomic Insights Into Diapause in the Wheat Stink Bug, Aelia rostrata.Archives of insect biochemistry and physiology · 2026Article
- Transcriptomic responses of red palm weevil (Coleoptera: Curculionidae) larvae to low-temperature exposure.Journal of insect science (Online) · 2026Article
- Temporal orchestration of transcriptional and epigenomic programming underlying maternal embryonic diapause in a cricket model.Communications biology · 2026Article
- Temperature regulation mechanisms of diapause inFrontiers in microbiology · 2026Article
- Lipid Properties and Metabolism in Response to Cold.Advances in experimental medicine and biology · 2026Review
- Stress in dipteran insects mass-reared for sterile insect technique applications.Insect science · 2025Review
- Thermal Ecology and Forensic Implications of Blow Fly (Family: Calliphoridae) Maggot Mass Dynamics: A Review.Insects · 2025Review
- Stress-induced organismal death is genetically regulated by the mTOR-Zeste-Phae1 axis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Noncanonical action of circadian clock genes controls winter diapause entry via the NuA4/TIP60 complex inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Influence of Hyperthermia Treatment on Varroa Infestation, Viral Infections, and Honey Bee Health in Beehives.Insects · 2025Review
- Molecular mechanisms and comparative transcriptomics of diapause in two corn rootworm species (Current research in insect science · 2025Article
- Endocrine and enzymatic shifts during insect diapause: a review of regulatory mechanisms.Frontiers in physiology · 2025Review
- Genome-wide analysis reveals transcriptional and translational changes during diapause of the Asian corn borer (Ostrinia furnacalis).BMC biology · 2024Article
- Arthropod-Borne Viruses of Human and Animal Importance: Overwintering in Temperate Regions of Europe during an Era of Climate Change.Microorganisms · 2024Review
- Heat Shock Response and Heat Shock Proteins: Current Understanding and Future Opportunities in Human Diseases.International journal of molecular sciences · 2024Review
- Prolonged Heat Stress during Winter Diapause Alters the Expression of Stress-Response Genes inInternational journal of molecular sciences · 2024Article
97 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Diapause, the dormancy common to overwintering insects, evokes a unique pattern of gene expression. In the flesh fly, most, but not all, of the fly's heat shock proteins (Hsps) are up-regulated. The diapause up-regulated Hsps include two members of the Hsp70 family, one member of the Hsp60 family (TCP-1), at least four members of the small Hsp family, and a small Hsp pseudogene. Expression of an Hsp70 cognate, Hsc70, is uninfluenced by diapause, and Hsp90 is actually down-regulated during diapause, thus diapause differs from common stress responses that elicit synchronous up-regulation of all Hsps. Up-regulation of the Hsps begins at the onset of diapause, persists throughout the overwintering period, and ceases within hours after the fly receives the signal to reinitiate development. The up-regulation of Hsps appears to be common to diapause in species representing diverse insect orders including Diptera, Lepidoptera, Coleoptera, and Hymenoptera as well as in diapauses that occur in different developmental stages (embryo, larva, pupa, adult). Suppressing expression of Hsp23 and Hsp70 in flies by using RNAi did not alter the decision to enter diapause or the duration of diapause, but it had a profound effect on the pupa's ability to survive low temperatures. We thus propose that up-regulation of Hsps during diapause is a major factor contributing to cold-hardiness of overwintering insects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.