ArticleProceedings of the National Academy of Sciences of the United States of America2007
Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8+ T cell memory.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures.Nature communications · 2025Article
- Prior infection with unrelated neurotropic virus exacerbates influenza disease and impairs lung T cell responses.Nature communications · 2024Article
- Elucidating Specificity Opens a Window to the Complexity of Both the Innate and Adaptive Immune Systems.Viral immunology · 2020Article
- Recalling the Future: Immunological Memory Toward Unpredictable Influenza Viruses.Frontiers in immunology · 2019Review
- CD8(+) T cells specific to a single Yersinia pseudotuberculosis epitope restrict bacterial replication in the liver but fail to provide sterilizing immunity.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Inducible chromatin priming is associated with the establishment of immunological memory in T cells.The EMBO journal · 2016Article
- Tracking cytotoxic potential in vivo.Cellular & molecular immunology · 2015Review
- Early CD8 T-cell memory precursors and terminal effectors exhibit equipotent in vivo degranulation.Cellular & molecular immunology · 2015Article
- Real-time tracking of cell cycle progression during CD8+ effector and memory T-cell differentiation.Nature communications · 2015Article
- Article
- Regulatory T Cells Modulate DNA Vaccine Immunogenicity at Early Time via Functional CD4(+) T Cells and Antigen Duration.Frontiers in immunology · 2015Article
- Cooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity.PLoS pathogens · 2013Article
- Induction of protective CD4+ T cell-mediated immunity by a Leishmania peptide delivered in recombinant influenza viruses.PloS one · 2012Article
- Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection.Frontiers in immunology · 2012Article
- Use it or lose it: establishment and persistence of T cell memory.Frontiers in immunology · 2012Article
- The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.Nature immunology · 2011Article
- Effect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor frequency and subsequent effector function.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Immunity to seasonal and pandemic influenza A viruses.Microbes and infection · 2011Review
- Impaired memory CD8 T cell responses against an immunodominant retroviral cryptic epitope.Virology · 2011Article
- Antigen-bearing dendritic cells regulate the diverse pattern of memory CD8 T-cell development in different tissues.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rapid recall of influenza virus-specific CD8(+) T cell effector function is protective, although our understanding of T cell memory remains incomplete. Recent debate has focused particularly on the CD62L lymph node homing receptor. The present analysis shows that although functional memory can be established from both CD62L(hi) and CD62L(lo) CD8(+) T cell subsets soon after initial encounter between naïve precursors and antigen, the optimal precursors are CD8(+)CD44(hi)CD25(lo) immune lymphocytes isolated from draining lymph nodes on day 3.5 after influenza virus infection. Analysis of primed T cells at different times after challenge indicates that the capacity to transfer memory is diminished at the peak of the primary cytotoxic T lymphocyte response, challenging speculations that the transition to memory first requires full differentiation to effector status. It seems that location rather than CD62Lhi/lo phenotype may be the more profitable focus for further dissection of the early establishment of T cell memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.