ArticleJournal of virology2007
Phylogenetic analysis and structural predictions of human adenovirus penton proteins as a basis for tissue-specific adenovirus vector design.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 61 citations in OpenAlex.
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- Genomic Epidemiological Characteristics of Enteric Adenovirus F40 and F41 in Yantai, China, from 2022 to 2023.Viruses · 2025Article
- Genetic analysis of human adenovirus type 108 circulating in China during 2014-2024.Virologica Sinica · 2025Article
- Molecular characterization and evolutionary analysis of human adenovirus type 55, related to febrile respiratory illness in the South Korean military.Virus genes · 2025Article
- Molecular characteristics of human adenovirus isolated from the 2024 influenza-like illness outbreaks in Suzhou City, China.Virology journal · 2025Article
- An Epidemic of Respiratory and Ocular Infections Caused by the Reemergence of a Recombinant Human Adenovirus, the Novel Type HAdV-B114 (P7H3F3).Journal of medical virology · 2025Article
- Epidemiological characteristics and genomic analysis of respiratory adenovirus in Lanzhou City from 2023 to 2025.Frontiers in cellular and infection microbiology · 2025Article
- Identification and characterization of a novel human adenovirus type HAdV-D116.Frontiers in microbiology · 2025Article
- Human adenovirus type 4 (HAdV-4) associated acute respiratory tract infection in children & genetic characteristics of HAdV-4 in China: a prospective multicenter study.BMC infectious diseases · 2024Article
- Pathogenicity and virulence of human adenovirus F41: Possible links to severe hepatitis in children.Virulence · 2023Review
- Prevalence and Molecular Characteristics of FAdV-4 from Indigenous Chicken Breeds in Yunnan Province, Southwestern China.Microorganisms · 2023Article
- Genetic characterization of human adenoviruses in patients using metagenomic next-generation sequencing in Hubei, China, from 2018 to 2019.Frontiers in microbiology · 2023Article
- Genome Analyses of Ten New Ape Adenoviruses with Similarity to HumanInternational journal of molecular sciences · 2022Article
- Article
- Evolution and diversity of human adenoviruses isolated from patients with keratoconjunctivitis.Iranian journal of microbiology · 2022Article
- First Record of HAdV-D20 Among Keratoconjunctivitis Patients in Iraq.Reports of biochemistry & molecular biology · 2022Article
- Adenovirus Structure: What Is New?International journal of molecular sciences · 2021Review
- The structure of enteric human adenovirus 41-A leading cause of diarrhea in children.Science advances · 2021Article
- Molecular Characteristics of Human Adenovirus Type 3 Circulating in Parts of China During 2014-2018.Frontiers in microbiology · 2021Article
- Innate immunity to adenovirus: lessons from mice.FEBS letters · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The penton base is a major capsid protein of human adenoviruses (HAdV) which forms the vertices of the capsid and interacts with hexon and fiber protein. Two hypervariable loops of the penton are exposed on the capsid surface. Sequences of these and 300 adjacent amino acid residues of all 51 HAdV and closely related simian adenoviruses were studied. Adjacent sequences and predicted overall secondary structure were conserved. Phylogenetic analysis revealed clustering corresponding to the HAdV species and recombination events in the origin of HAdV prototypes. All HAdV except serotypes 40 and 41 of species F exhibited an integrin binding RGD motif in the second loop. The lengths of the loops (HVR1 and RGD loops) varied significantly between HAdV species with the longest RGD loop observed in species C and the longest HVR1 in species B. Long loops may permit the insertion of motifs that modify tissue tropism. Genetic analysis of HAdV prime strain p17'H30, a neutralization variant of HAdV-D17, indicated the significance of nonhexon neutralization epitopes for HAdV immune escape. Fourteen highly conserved motifs of the penton base were analyzed by site-directed mutagenesis of HAdV-D8 and tested for sustained induction of early cytopathic effects. Thus, three new motifs essential for penton base function were identified additionally to the RGD site, which interacts with a secondary cellular receptor responsible for internalization. Therefore, our penton primary structure data and secondary structure modeling in combination with the recently published fiber knob sequences may permit the rational design of tissue-specific adenoviral vectors.
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