ArticleLearning & memory (Cold Spring Harbor, N.Y.)2007
Protection from premature habituation requires functional mushroom bodies in Drosophila.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed.
- Semi-Automated Assessment of Long-Term Olfactory Habituation inBio-protocol · 2024Article
- Article
- Differential Effects of Human Tau Isoforms to Neuronal Dysfunction and Toxicity in the Drosophila CNS.International journal of molecular sciences · 2022Article
- The Two Cysteines of Tau Protein Are Functionally Distinct and Contribute Differentially to Its PathogenicityThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Article
- Domain-Specific Cognitive Impairments in Humans and Flies With Reduced CYFIP1 Dosage.Biological psychiatry · 2019Article
- Habituation Learning Is a Widely Affected Mechanism in Drosophila Models of Intellectual Disability and Autism Spectrum Disorders.Biological psychiatry · 2019Article
- Intellectual disability and autism spectrum disorders 'on the fly': insights fromDisease models & mechanisms · 2019Review
- Temporally specific engagement of distinct neuronal circuits regulating olfactory habituation ineLife · 2018Article
- Cyclic AMP-dependent plasticity underlies rapid changes in odor coding associated with reward learning.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Habituation, sensitization, and Pavlovian conditioning.Frontiers in integrative neuroscience · 2014Article
- Article
- The course of habituation of the proboscis extension reflex can be predicted by sucrose responsiveness in Drosophila.PloS one · 2012Article
- The origin of behavioral bursts in decision-making circuitry.PLoS computational biology · 2011Article
- Mind the gap: olfactory trace conditioning in honeybees.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Appetitive and aversive visual learning in freely moving Drosophila.Frontiers in behavioral neuroscience · 2010Article
- Neurogenetic approaches to habituation and dishabituation in Drosophila.Neurobiology of learning and memory · 2009Review
- A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Circadian modulation of short-term memory in Drosophila.Learning & memory (Cold Spring Harbor, N.Y.) · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diminished responses to stimuli defined as habituation can serve as a gating mechanism for repetitive environmental cues with little predictive value and importance. We demonstrate that wild-type animals diminish their responses to electric shock stimuli with properties characteristic of short- and long-term habituation. We used spatially restricted abrogation of neurotransmission to identify brain areas involved in this behavioral response. We find that the mushroom bodies and, in particular, the alpha/beta lobes appear to guard against habituating prematurely to repetitive electric shock stimuli. In addition to protection from premature habituation, the mushroom bodies are essential for spontaneous recovery and dishabituation. These results reveal a novel modulatory role of the mushroom bodies on responses to repetitive stimuli in agreement with and complementary to their established roles in olfactory learning and memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.