ReviewCytokine & growth factor reviews
Regulation of cell junction dynamics by cytokines in the testis: a molecular and biochemical perspective.
Review in Cytokine & growth factor reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
- Cannabinoid Receptors Modulate Physiological Remodelling of the Blood-Testis Barrier.Journal of cellular physiology · 2025Article
- Contribution and Regulation of HIF-1α in Testicular Injury Induced by Diabetes Mellitus.Biomolecules · 2025Review
- Viral Infections and Male Infertility: A Comprehensive Review of the Role of Oxidative Stress.Frontiers in reproductive health · 2022Review
- Role of p38 MAPK Signalling in Testis Development and Male Fertility.Oxidative medicine and cellular longevity · 2022Review
- Impact of Vitamin C on Gene Expression Profile of Inflammatory and Anti-Inflammatory Cytokines in the Male Partners of Couples with Recurrent Pregnancy Loss.International journal of inflammation · 2022Article
- E3 ubiquitin ligase ASB17 is required for spermiation in mice.Translational andrology and urology · 2021Article
- Toxicological effects of bioactive peptide fractions obtained fromThe journal of venomous animals and toxins including tropical diseases · 2020Article
- Cell polarity proteins and spermatogenesis.Seminars in cell & developmental biology · 2016Review
- New insights into FAK function and regulation during spermatogenesis.Histology and histopathology · 2014Review
- Role of non-receptor protein tyrosine kinases in spermatid transport during spermatogenesis.Seminars in cell & developmental biology · 2014Review
- Pleiotropic Activities of HGF/c-Met System in Testicular Physiology: Paracrine and Endocrine Implications.Frontiers in endocrinology · 2014Review
- Signalling pathways regulating the blood-testis barrier.The international journal of biochemistry & cell biology · 2013Review
- Article
- The Drosophila cyst stem cell lineage: Partners behind the scenes?Spermatogenesis · 2012Article
- Metabolic regulation is important for spermatogenesis.Nature reviews. Urology · 2012Review
- The blood-testis barrier and its implications for male contraception.Pharmacological reviews · 2012Review
- Transcriptional regulation of cell adhesion at the blood-testis barrier and spermatogenesis in the testis.Advances in experimental medicine and biology · 2012Review
- Expression of Itch in Sertoli cells is controlled via the interaction of E2F1/DP1 complex with E2F and GATA motifs.Spermatogenesis · 2011Article
- A local autocrine axis in the testes that regulates spermatogenesis.Nature reviews. Endocrinology · 2010Review
- Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis.Biology of reproduction · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Studies in the past decade in the field have demonstrated the significance of cytokines in regulating epithelial and endothelial cell junctions including tight and anchoring junctions in multiple organs including the testis. There are mounting evidences in recent years that cytokines play a crucial role in the restructuring of junctions at the Sertoli-Sertoli and Sertoli-germ cell interface in the seminiferous epithelium during spermatogenesis. These earlier studies, however, were focused on the effects of cytokines in maintaining the steady-state protein levels of integral membrane proteins at the sites of the blood-testis barrier (BTB) and anchoring junctions at the Sertoli-Sertoli and Sertoli-germ cell interface, such as basal and apical ectoplasmic specialization, respectively. The molecular pathway(s) and/or mechanism(s) underlying these effects remained virtually unexplored until very recently. Herein, we summarize and provide some discussions on studies that focused on the role of cytokines in regulating junction restructuring events in epithelia from a molecular and biochemical perspective. Specifically, we use the adult rat or mouse testis as a model to highlight the significance of transcriptional and translational regulation. Specific areas of research that require further attentions are also highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.