ArticleJournal of autoimmunity2007
Large functional repertoire of regulatory T-cell suppressible autoimmune T cells in scurfy mice.
Article in Journal of autoimmunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Article
- Conditional deletion of CD25 in the corneal epithelium reveals sex differences in barrier disruption.The ocular surface · 2023Article
- Regulatory T-cell deficiency leads to features of autoimmune liver disease overlap syndrome in scurfy mice.Frontiers in immunology · 2023Article
- Effects of Glycemic Variability on Regulatory T Cells in Patients with Type 2 Diabetes and Kidney Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- In mouse chronic pancreatitis CD25Nature communications · 2022Article
- The Biology and Molecular Basis of Organ Transplant Rejection.Handbook of experimental pharmacology · 2022Article
- The double-edged sword of Tregs in M tuberculosis, M avium, and M absessus infection.Immunological reviews · 2021Review
- Autoantibodies targeting TRIM72 compromise membrane repair and contribute to inflammatory myopathy.The Journal of clinical investigation · 2020Article
- HeliosEuropean journal of immunology · 2019Article
- Regulatory T cells in acute and chronic kidney diseases.American journal of physiology. Renal physiology · 2018Review
- Activation of CD4 and CD8 T cell receptors and regulatory T cells in response to human proteins.PeerJ · 2018Article
- IL233, A Novel IL-2 and IL-33 Hybrid Cytokine, Ameliorates Renal Injury.Journal of the American Society of Nephrology : JASN · 2017Article
- γδ T Cells Protect the Liver and Lungs of Mice from Autoimmunity Induced by Scurfy Lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease.Arthritis research & therapy · 2015Article
- T-bet regulates differentiation of forkhead box protein 3+ regulatory T cells in programmed cell death-1-deficient mice.Clinical and experimental immunology · 2015Article
- Clinical heterogeneity of immunodysregulation, polyendocrinopathy, enteropathy, X-linked: pulmonary involvement as a non-classical disease manifestation.Journal of clinical immunology · 2014Article
- The forkhead transcription factor, FOXP3: a critical role in male fertility in mice.Biology of reproduction · 2014Article
- Aberrant muscle antigen exposure in mice is sufficient to cause myositis in a Treg cell-deficient milieu.Arthritis and rheumatism · 2013Article
- A novel function of IL-2: chemokine/chemoattractant/retention receptor genes induction in Th subsets for skin and lung inflammation.Journal of autoimmunity · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Scurfy mice which lacks functional Foxp3 transcription factor and CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells, spontaneously develop autoimmune responses against skin, lung, liver and tail. However, many organs/tissues are spared from autoimmune attack. Here, we demonstrate that scurfy mice contain dormant autoimmune T cells that induced new diseases such as sialoadenitis, dacryoadenitis, pancreatitis, gastritis, intestinal inflammation, colitis, and myositis in RAG-1 KO mice. Inflammation in as many as 12 organs/tissues was consistently induced in individual recipients with scurfy lymph node cells containing as few as 1.25 x 10(6) CD4(+) T cells. Moreover, transfer of the multiple organ autoimmune diseases could be suppressed by as little as 0.5 x 10(6) CD4(+)CD25(+) Treg cells, mediated by inhibiting autoimmune T-cell expansion. Our study provides evidence for the presence of a large repertoire of autoimmune lymphocytes against various organs/tissues in scurfy mice as well as Treg cells in B6 mice capable of suppressing the expansion of these autoimmune lymphocytes. Various conditions that control the expression of autoimmune T cells are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.