ReviewAlcohol (Fayetteville, N.Y.)2007
Modulation of GABAA receptors in cerebellar granule neurons by ethanol: a review of genetic and electrophysiological studies.
Review in Alcohol (Fayetteville, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 67 citations in OpenAlex.
- Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025Review
- Cerebellar α6GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Article
- Chronic Ethanol Exposure Enhances Facial Stimulation-Evoked Mossy Fiber-Granule Cell Synaptic TransmissionFrontiers in systems neuroscience · 2021Article
- Alcohol and IL-6 Alter Expression of Synaptic Proteins in Cerebellum of Transgenic Mice with Increased Astrocyte Expression of IL-6.Neuroscience · 2020Article
- Missense Gamma-Aminobutyric Acid Receptor Polymorphisms Are Associated with Reaction Time, Motor Time, and Ethanol EffectsFrontiers in cellular neuroscience · 2018Article
- The Cerebellar GABAHandbook of experimental pharmacology · 2018Article
- Synaptic targets: Chronic alcohol actions.Neuropharmacology · 2017Review
- Recreational concentrations of alcohol enhance synaptic inhibition of cerebellar unipolar brush cells via pre- and postsynaptic mechanisms.Journal of neurophysiology · 2017Article
- Ethanol Modulates the Spontaneous Complex Spike Waveform of Cerebellar Purkinje Cells RecordedFrontiers in cellular neuroscience · 2017Article
- Ethanol modulates facial stimulation-evoked outward currents in cerebellar Purkinje cells in vivo in mice.Scientific reports · 2016Article
- Cell-type-specific tonic GABA signaling in the rat central amygdala is selectively altered by acute and chronic ethanol.Addiction biology · 2016Article
- Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?Frontiers in cellular neuroscience · 2016Review
- Mini-Review: Effects of Ethanol on GABAA Receptor-Mediated Neurotransmission in the Cerebellar Cortex--Recent Advances.Cerebellum (London, England) · 2015Review
- Acute ethanol exposure inhibits silencing of cerebellar Golgi cell firing induced by granule cell axon input.Frontiers in integrative neuroscience · 2014Article
- Opposite actions of alcohol on tonic GABA(A) receptor currents mediated by nNOS and PKC activity.Nature neuroscience · 2013Article
- Sex differences in neuroadaptation to alcohol and withdrawal neurotoxicity.Pflugers Archiv : European journal of physiology · 2013Review
- Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Neurosteroids and GABAergic signaling in health and disease.Biomolecular concepts · 2013Review
- Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition.Nature communications · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Cerebellar granule neurons (CGNs) receive inhibitory input from Golgi cells in the form of phasic and tonic currents that are mediated by postsynaptic and extrasynaptic gamma-aminobutyric acid type A (GABAA) receptors, respectively. Extrasynaptic receptors are thought to contain alpha6betaxdelta subunits. Here, we review studies on ethanol (EtOH) modulation of these receptors, which have yielded contradictory results. Although studies with recombinant receptors expressed in Xenopus oocytes indicate that alpha6beta3delta receptors are potently enhanced by acute exposure to low (>or=3 mM) EtOH concentrations, this effect was not observed when these receptors were expressed in Chinese hamster ovary cells. Slice recordings of CGNs have consistently shown that EtOH increases the frequency of phasic spontaneous inhibitory postsynaptic currents (sIPSCs), as well as the tonic current amplitude and noise. However, there is a lack of consensus as to whether EtOH directly acts on extrasynaptic receptors or modulates them indirectly; that is, via an increase in spillover of synaptically released GABA. It was recently demonstrated that an R to Q mutation of amino acid 100 of the alpha6 subunit increases the effect of EtOH on both sIPSCs and tonic current. These electrophysiological findings have not been reproducible in our hands. Moreover, it was shown the alpha6-R100Q mutation enhances sensitivity to the motor-impairing effects of EtOH in outbred Sprague-Dawley rats, but this was not observed in a line of rats selectively bred for high sensitivity to EtOH-induced motor alterations (Alcohol Non-Tolerant rats). We conclude that currently there is insufficient evidence conclusively supporting a direct potentiation of extrasynaptic GABAA receptors following acute EtOH exposure in CGNs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.