ReviewNeuron2007
The neurobiologist's guide to structural biology: a primer on why macromolecular structure matters and how to evaluate structural data.
Review in Neuron, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Analysis of cyclohexane, cyclopentane, and benzene conformations in ligands for PDB X-ray structures using the Hill-Reilly approach.Journal of cheminformatics · 2026Article
- Applications of Molecular Dynamics Simulation in Protein Study.Membranes · 2022Review
- Surface-Induced Dissociation of Anionic vs Cationic Native-Like Protein Complexes.Journal of the American Chemical Society · 2021Article
- Modeling Conformationally Flexible Proteins With X-ray Scattering and Molecular Simulations.Computational and structural biotechnology journal · 2019Review
- Molecular Dynamics Simulation for All.Neuron · 2018Review
- Multiscale modeling in the clinic: diseases of the brain and nervous system.Brain informatics · 2017Review
- Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealed by intrinsic tryptophan fluorescence quenching.The Journal of biological chemistry · 2015Article
- Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Journal of molecular biology · 2015Review
- Insights into the molecular foundations of electrical excitation.Journal of molecular biology · 2015Article
- Structural biology of TRP channels.Handbook of experimental pharmacology · 2014Review
- Protein crystallography for aspiring crystallographers or how to avoid pitfalls and traps in macromolecular structure determination.The FEBS journal · 2013Review
- Biochemical approaches to C4 photosynthesis evolution studies: the case of malic enzymes decarboxylases.Photosynthesis research · 2013Review
- Conduits of life's spark: a perspective on ion channel research since the birth of neuron.Neuron · 2013Review
- Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation.Journal of molecular biology · 2013Article
- Resolution-by-proxy: a simple measure for assessing and comparing the overall quality of NMR protein structures.Journal of biomolecular NMR · 2012Article
- Crystallographic basis for calcium regulation of sodium channels.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.The EMBO journal · 2010Article
- Fluorescence applications in molecular neurobiology.Neuron · 2010Review
- Searching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function.Molecular bioSystems · 2009Review
- Divide and conquer: high resolution structural information on TRP channel fragments.The Journal of general physiology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Structural biology now plays a prominent role in addressing questions central to understanding how excitable cells function. Although interest in the insights gained from the definition and dissection of macromolecular anatomy is high, many neurobiologists remain unfamiliar with the methods employed. This primer aims to help neurobiologists understand approaches for probing macromolecular structure and where the limits and challenges remain. Using examples of macromolecules with neurobiological importance, the review covers X-ray crystallography, electron microscopy (EM), small-angle X-ray scattering (SAXS), and nuclear magnetic resonance (NMR) and biophysical methods with which these approaches are often paired: isothermal titration calorimetry (ITC), equilibrium analytical ultracentifugation, and molecular dynamics (MD).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.