ReviewCurrent osteoporosis reports2007
The biology of osteocytes.
Review in Current osteoporosis reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Cortical bone porosity is spatially heterogeneous and VEGF dependent in male bone.Disease models & mechanisms · 2026Article
- The Past, Present, and Future of Genetically Engineered Mouse Models for Skeletal Biology.Biomolecules · 2023Review
- Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue.Scientific reports · 2023Article
- Recombinant sclerostin antagonizes effects of ex vivo mechanical loading in trabecular bone and increases osteocyte lacunar size.American journal of physiology. Cell physiology · 2018Article
- Lacunar-canalicular network in femoral cortical bone is reduced in aged women and is predominantly due to a loss of canalicular porosity.Bone reports · 2017Article
- Acute and Stress-related Injuries of Bone and Cartilage: Pertinent Anatomy, Basic Biomechanics, and Imaging Perspective.Radiology · 2016Review
- Multiple myeloma in the marrow: pathogenesis and treatments.Annals of the New York Academy of Sciences · 2016Review
- Article
- The osteocyte as a therapeutic target in the treatment of osteoporosis.Therapeutic advances in musculoskeletal disease · 2014Review
- Ginseng saponins and the treatment of osteoporosis: mini literature review.Journal of ginseng research · 2013Review
- Review
- Quantifying load-induced solute transport and solute-matrix interaction within the osteocyte lacunar-canalicular system.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Osteocytic osteolysis: time for a second look?BoneKEy reports · 2012Review
- Article
- Development and mineralization of embryonic avian scleral ossicles.Molecular vision · 2012Article
- Phenotypic characterization of osteoarthritic osteocytes from the sclerotic zones: a possible pathological role in subchondral bone sclerosis.International journal of biological sciences · 2012Article
- Real-time measurement of solute transport within the lacunar-canalicular system of mechanically loaded bone: direct evidence for load-induced fluid flow.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Potential new drug targets for osteoporosis.Nature clinical practice. Rheumatology · 2009Review
- Mammalian hibernation as a model of disuse osteoporosis: the effects of physical inactivity on bone metabolism, structure, and strength.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteocytes, the most abundant cell type in bone, remain the least characterized. Several theories have been proposed regarding their function, including osteolysis, sensing the strains produced in response to mechanical loading of bones, and producing signals that affect the function of osteoblasts and osteoclasts and hence, bone turnover. This review also discusses the role of osteocyte apoptosis in targeted bone remodeling and proposes that the occurrence of osteocyte apoptosis is consistent with the description of apoptosis as an essential homeostatic mechanism for the healthy maintenance of tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.