Evidence map›Paper›PMID 17521506›Full record

ReviewCurrent osteoporosis reports2007

Effects of microarchitecture on bone strength.

Jacqueline C van der Linden, Harrie Weinans

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current osteoporosis reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02186600 (Randomized Control Trial of Bone Loading Exercises Versus Risedronate on Bone Health in Post-Menopausal Women), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02186600 phase3completednot on this mapstarted 2015, after this paper: background citation

Randomized Control Trial of Bone Loading Exercises Versus Risedronate on Bone Health in Post-Menopausal Women

TypeinterventionalSponsorUniversity of NebraskaRan2015 to 2019Enrolled276ConditionsOsteopeniaArmsCalcium Carbonate, Vitamin D3, Risedronate, Bone-loading exercises
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Choose your mother wisely: the familial resemblance of bone adaptation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Regenerative Approaches for the Treatment of Large Bone Defects.Tissue engineering. Part B, Reviews · 2021
    Review
  8. A feasibility study on microwave imaging of bone for osteoporosis monitoring.Medical & biological engineering & computing · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Measurement of cortical porosity of the proximal femur improves identification of women with nonvertebral fragility fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Article
  14. Article
  15. Women with previous fragility fractures can be classified based on bone microarchitecture and finite element analysis measured with HR-pQCT.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013
    Article
  16. Article
  17. Evaluation of trabecular microarchitecture in nonosteoporotic postmenopausal women with and without fracture.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jacqueline C van der LindenErasmus MC, Department of Orthopaedics, 3000 DR Rotterdam, The Netherlands. j.vanderlinden@erasmusmc.nl
Harrie Weinans

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone strength and stiffness depend strongly on bone mass, but they also depend on the microarchitecture and tissue quality of both cancellous and cortical bone. All these aspects differ between individuals and between anatomic sites. This review discusses ways to characterize the three-dimensional cancellous architecture as well as changes in architecture and bone composition caused by bone remodeling. The methods used range from detailed descriptions of sizes and distances in cancellous bone to coarser texture analysis methods using clinical data. As the resolution of clinical images increases, it may become possible to use knowledge of the relationship between bone microarchitecture and strength to predict fracture risk clinically.

Indexed as

Biomechanical PhenomenaBone and BonesBone DensityBone RemodelingHumansTomography, X-Ray Computed

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.