ArticleBMC clinical pathology2007
The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma.
Article in BMC clinical pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- The prognostic role of Ki-67/MIB-1 in cervical cancer: a systematic review with meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis.Cancer treatment reviews · 2009Pooled it
- Role of Immunohistochemistry in the Diagnosis and Clinicopathological Stratification of Gliomas.Cureus · 2026Article
- A case of primary lung cancer requiring differentiation from metastatic cervical cancer.Respirology case reports · 2023Article
- Review
- Article
- Glycogen synthase kinase 3β and cyclin D1 expression in cervical carcinogenesis.Obstetrics & gynecology science · 2016Article
- Association between p21 Ser31Arg polymorphism and the development of cervical lesion in women infected with high risk HPV.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Correlation of P16 (Ink4a) and CK17 to HPV (16E6+18E6) in Premalignant and Malignant Lesions of Uterine Cervix: A Clinicopathologic Study.Iranian journal of pathology · 2016Article
- A comparative analysis of clinical and molecular factors with the stage of cervical cancer in a Brazilian cohort.PloS one · 2013Article
- Candidates for tumor markers of cervical cancer discovered by proteomic analysis.Journal of Korean medical science · 2012Article
- Human papillomavirus infection and its possible correlation with p63 expression in cervical cancer in Japan, Mongolia, and Myanmar.Acta histochemica et cytochemica · 2009Article
- DEK proto-oncogene expression interferes with the normal epithelial differentiation program.The American journal of pathology · 2009Article
- Gene expression profile of cervical and skin tissues from human papillomavirus type 16 E6 transgenic mice.BMC cancer · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman papillomavirus (HPV) 16 and 18 are associated with cervical carcinogenesis through an interaction between HPV oncogenic proteins and cell cycle regulatory genes. However, the exact pathogenetic mechanisms are not determined yet.
methodsWe investigated 43 invasive squamous cell carcinoma (ISCC), 38 CIN III, 11 CINII and 18 CINI for cyclin D1, cyclin E, CDK4, p53, mdm-2, p21(waf), p27, p16(INK4A), Rb and Ki-67 aberrations using immunohistochemistry and molecular techniques. Twenty samples of normal cervical tissues (NCT) were taken as a control.
resultsThere was a significant increase in the expression of Ki-67, cyclin E, CDK4, p16(INK4A), Rb (p= 0.003, 0.001, 0.001, 0.01) and a significant decrease in p27(KIP1) from NCT to ISCC (p = 0.003). Increased cyclin D1, p21(waf), p53, mdm-2 expression, homozygous deletion (HZD) and promoter methylation (PM) of the Rb were detected in CINIII and ISCC only. On univariate analysis; tumor size, differentiation, lymph node status, FIGO stage, Ki-67, cyclin D1, p53 and p27(KIP1) are significantly associated with reduced overall survival (OS) while on multivariate analysis; only FIGO stage, Ki-67, cyclin D1, p53 and p27(KIP1) were significant.
conclusion1) Aberrations involving p27(KIP1), cyclin E, CDK4, p16(INK4A) are considered early events in HPV 16 and 18-associated cervical carcinoma, whereas cyclin D1 and p53 pathway abnormalities are considered late events. 2) Immunohistochemical tests for p16(INK4A) and cyclin E, could help in early diagnosis of cervical carcinoma. 3) Only FIGO stage p53, cyclin D1, p27(KIP1) and Ki-67 are independent prognostic factors that might help in predicting outcome of cervical cancer patients.
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Registered trials
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