ArticleGenome research2007
Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
121 citing papers in PubMed, 1 synthesis or guideline pooled it, 247 citations in OpenAlex.
- Guideline
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- Botulinum Toxin: A Comprehensive Review of Its Molecular Architecture and Mechanistic Action.International journal of molecular sciences · 2025Review
- An Outbreak of Foodborne Botulism Caused byChina CDC weekly · 2024Article
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- Metagenomics uncovers dietary adaptations for chitin digestion in the gut microbiota of convergent myrmecophagous mammals.mSystems · 2023Article
- Hacking the Immune Response to Solid Tumors: Harnessing the Anti-Cancer Capacities of Oncolytic Bacteria.Pharmaceutics · 2023Review
- Physical Treatments to ControlFoods (Basel, Switzerland) · 2023Review
- Genomic Diversity, Competition, and Toxin Production by Group I and IIMicroorganisms · 2022Article
- Specific Isolation ofInternational journal of molecular sciences · 2022Article
- Review
- Recent Trends in Protective Textiles against Biological Threats: A Focus on Biological Warfare Agents.Polymers · 2022Review
- Autoinducing peptide-based quorum signaling systems in Clostridioides difficile.Current opinion in microbiology · 2022Review
- Occurrence of genes encoding spore germination inMicrobial genomics · 2022Article
- Posttranslational Regulation of Botulinum Neurotoxin Production in Clostridium botulinum Hall A-mSphere · 2021Article
- barCoder: a tool to generate unique, orthogonal genetic tags for qPCR detection.BMC bioinformatics · 2021Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
34 authors at 5 institutions in 2 countries.
Funding
Abstract
Clostridium botulinum is a heterogeneous Gram-positive species that comprises four genetically and physiologically distinct groups of bacteria that share the ability to produce botulinum neurotoxin, the most poisonous toxin known to man, and the causative agent of botulism, a severe disease of humans and animals. We report here the complete genome sequence of a representative of Group I (proteolytic) C. botulinum (strain Hall A, ATCC 3502). The genome consists of a chromosome (3,886,916 bp) and a plasmid (16,344 bp), which carry 3650 and 19 predicted genes, respectively. Consistent with the proteolytic phenotype of this strain, the genome harbors a large number of genes encoding secreted proteases and enzymes involved in uptake and metabolism of amino acids. The genome also reveals a hitherto unknown ability of C. botulinum to degrade chitin. There is a significant lack of recently acquired DNA, indicating a stable genomic content, in strong contrast to the fluid genome of Clostridium difficile, which can form longer-term relationships with its host. Overall, the genome indicates that C. botulinum is adapted to a saprophytic lifestyle both in soil and aquatic environments. This pathogen relies on its toxin to rapidly kill a wide range of prey species, and to gain access to nutrient sources, it releases a large number of extracellular enzymes to soften and destroy rotting or decayed tissues.
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Registered trials
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