Evidence map›Paper›PMID 17519390›Full record

ArticleBlood2007

Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation.

Takaya Murakami, Xin Chen, Koji Hase, Ayako Sakamoto, Chie Nishigaki, Hiroshi Ohno

Abstract read
In one paragraph

Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Takaya MurakamiLaboratory for Epithelial Immunobiology, Rikagaku Kenkyusho (RIKEN) Research Center for Allergy and Immunology, Yokohama, Japan.
Xin Chen
Koji Hase
Ayako Sakamoto
Chie Nishigaki
Hiroshi Ohno
RIKEN Center for Integrative Medical Sciences · JPScience Applications International Corporation (United States) · USYokohama City University · JP

Funding

NCI NIH HHS N01 CO012400NCI NIH HHS N01-CO12400
6 · The paper itself

Abstract

Follicular dendritic cells (FDCs) form a reticular FDC network in the lymphoid follicle that is essential for the retention and presentation of native antigens in the form of antigen-antibody immune complexes (ICs) to B cells during secondary immune response. Although the presence of migrating precursors of FDCs has been hypothesized, their entity has not been elucidated. Here we report the identification of murine splenic CD19(-)CD11c(-)CD35(+)B220(+) cells as an inducer of FDC network formation. We demonstrated that CD19(-)-CD11c(-)CD35(+)B220(+) cells, together with stromal cells, had the remarkable ability to form lymphoid-follicle-like structures that contained B220(+)FDC-M1(+) reticular cells originally derived from CD19(-)-CD11c(-)CD35(+)B220(+) cells in the CD35(+) reticulum. Our results indicate that CD19(-)CD11c(-)CD35(+)B220(+) cells function as an inducer of FDC network formation and that the interaction between CD19(-)CD11c(-)CD35(+)B220(+) cells and stromal cells is required to initiate lymphoid follicle formation.

Indexed as

AnimalsAntigens, CD19Cell DifferentiationCell LineageDendritic Cells, FollicularFlow CytometryGreen Fluorescent ProteinsImmunophenotypingKiller Cells, NaturalLeukocyte Common AntigensMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Complement 3bAntigens, CD19enhanced green fluorescent proteinGreen Fluorescent ProteinsLeukocyte Common AntigensReceptors, Complement 3bTumor Necrosis Factor-alpha

Identifiers

PMID17519390
PMCPMC1939903
OpenAlexW2046967191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.