ArticleProceedings of the National Academy of Sciences of the United States of America2007
Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of drugs that modify the circadian system's phase-shifting responses to light exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Sildenafil reduced neuroinflammation and improved white matter injury in a rat model of term neonatal hypoxic-ischemic encephalopathy.Scientific reports · 2025Article
- Estrogen signaling is necessary for the sex difference in simulated jet lag in mice.American journal of physiology. Endocrinology and metabolism · 2025Article
- Conserved age-related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories.Aging cell · 2022Article
- Photic Entrainment of the Circadian System.International journal of molecular sciences · 2022Review
- A wrinkle in time: circadian biology in pulmonary vascular health and disease.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Receptor Guanylyl Cyclase C and Cyclic GMP in Health and Disease: Perspectives and Therapeutic Opportunities.Frontiers in endocrinology · 2022Review
- Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.Nature communications · 2021Article
- Circadian rhythm as a therapeutic target.Nature reviews. Drug discovery · 2021Review
- Exceptional Entrainment of Circadian Activity Rhythms With Manipulations of Rhythm Waveform in Male Syrian Hamsters.The Yale journal of biology and medicine · 2019Article
- A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies.International journal of molecular sciences · 2019Review
- Renal Integrin-Linked Kinase Depletion Induces Kidney cGMP-Axis Upregulation: Consequences on Basal and Acutely Damaged Renal Function.Molecular medicine (Cambridge, Mass.) · 2016Article
- ESR1 and ESR2 differentially regulate daily and circadian activity rhythms in female mice.Endocrinology · 2014Article
- Minutes, days and years: molecular interactions among different scales of biological timing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Daily cycling of nitric oxide synthase (NOS) in the hippocampus of pigeons (C. livia).Journal of circadian rhythms · 2013Article
- How to fix a broken clock.Trends in pharmacological sciences · 2013Article
- MDMA induces Per1, Per2 and c-fos gene expression in rat suprachiasmatic nuclei.Psychopharmacology · 2012Article
- cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents.PloS one · 2012Article
- Unwinding the molecular basis of interval and circadian timing.Frontiers in integrative neuroscience · 2011Article
- Role of clock genes in gastrointestinal motility.American journal of physiology. Gastrointestinal and liver physiology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian circadian rhythms are generated by a master clock located in the suprachiasmatic nuclei and entrained by light-activated signaling pathways. In hamsters, the mechanism responsible for light-induced phase advances involves the activation of guanylyl cyclase, cGMP and its related kinase (PKG). It is not completely known whether interference with this pathway affects entrainment of the clock, including adaptation to changing light schedules. Here we report that cGMP-specific phosphodiesterase 5 is present in the hamster suprachiasmatic nuclei, and administration of the inhibitor sildenafil (3.5 mg/kg, i.p.) enhances circadian responses to light and decreases the amount of time necessary for reentrainment after phase advances of the light-dark cycle. These results suggest that sildenafil may be useful for treatment of circadian adaptation to environmental changes, including transmeridian eastbound flight schedules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.