ArticleThe Journal of experimental medicine2007
Mice lacking NKCC1 are protected from development of bacteremia and hypothermic sepsis secondary to bacterial pneumonia.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Loss of NR2F6 Protects from Salmonella Typhimurium Infection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Modulation of Cerebrospinal Fluid Dysregulation via a SPAK and OSR1 Targeted Framework Nucleic Acid in Hydrocephalus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Surfactant Attenuates Air Embolism-Induced Lung Injury by Suppressing NKCC1 Expression and NF-κB Activation.Inflammation · 2021Article
- Nonionic surfactant attenuates acute lung injury by restoring epithelial integrity and alveolar fluid clearance.International journal of medical sciences · 2021Article
- Acute Hyperglycemia Aggravates Lung Injury via Activation of the SGK1-NKCC1 Pathway.International journal of molecular sciences · 2020Article
- Novel mechanisms regulating endothelial barrier function in the pulmonary microcirculation.The Journal of physiology · 2019Review
- Inhibition of NKCC1 Modulates Alveolar Fluid Clearance and Inflammation in Ischemia-Reperfusion Lung Injury via TRAF6-Mediated Pathways.Frontiers in immunology · 2018Article
- Loop Diuretics Diminish Hemolysis Induced by α-Hemolysin from Escherichia coli.The Journal of membrane biology · 2017Article
- Inflammatory Responses Regulating Alveolar Ion Transport during Pulmonary Infections.Frontiers in immunology · 2017Review
- Cytokine-Regulation of NaFrontiers in immunology · 2017Review
- Perspective of future drugs targeting sterile 20/SPS1-related proline/alanine-rich kinase for blood pressure control.World journal of cardiology · 2015Article
- Combustion smoke-induced inflammation in the olfactory bulb of adult rats.Journal of neuroinflammation · 2014Article
- COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination.American journal of physiology. Cell physiology · 2013Article
- Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts.American journal of physiology. Cell physiology · 2013Review
- Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Article
- Nuclear factor-kappaB is a critical mediator of Ste20-like proline-/alanine-rich kinase regulation in intestinal inflammation.The American journal of pathology · 2008Article
- CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The effect of valproic acid on SLC5A8 expression in gonad-intact and gonadectomized rat thymocytes.International journal of immunopathology and pharmacologyArticle
- The roles of sodium-potassium-chloride cotransporter isoform-1 in acute lung injury.Tzu chi medical journalReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The contribution of the Na(+)-K(+)-Cl(-) transporter (NKCC1) to fluid in ion transport and fluid secretion in the lung and in other secretory epithelia has been well established. Far less is known concerning the role of this cotransporter in the physiological response of the pulmonary system during acute inflammation. Here we show that mice lacking this transporter are protected against hypothermic sepsis and bacteremia developing as a result of Klebsiella pneumoniae infection in the lung. In contrast, this protection was not observed in NKCC1(-/-) mice with K. pneumoniae-induced peritonitis. Although overall recruitment of cells to the lungs was not altered, the number of cells present in the airways was increased in the NKCC1(-/-) animals. Despite this robust inflammatory response, the increase in vascular permeability observed in this acute inflammatory model was attenuated in the NKCC1(-/-) animals. Our studies suggest that NKCC1 plays a unique and untoward unrecognized role in acute inflammatory responses in the lung and that specific inhibition of this NKCC isoform could be beneficial in treatment of sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.