ArticleThe Journal of cell biology2007
Intranucleolar sites of ribosome biogenesis defined by the localization of early binding ribosomal proteins.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 89 citations in OpenAlex.
- Convergent nuclear proteostasis alterations across 40S ribosomal protein deficiencies.Nature communications · 2026Article
- rRNA intermediates associate with nucleolar reshaping in C. elegans.Nucleic acids research · 2026Article
- Ribosomal protein L24 mediates mammalian microRNA processing in an evolutionarily conserved manner.Cellular and molecular life sciences : CMLS · 2024Article
- Viscoelasticity and advective flow of RNA underlies nucleolar form and function.Molecular cell · 2023Article
- The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.Science advances · 2021Article
- High resolution RNA-seq profiling of genes encoding ribosomal proteins across different organs and developmental stages inPlant direct · 2021Article
- Arabidopsis paralogous genes RPL23aA and RPL23aB encode functionally equivalent proteins.BMC plant biology · 2020Article
- Article
- ZFAS1: a long noncoding RNA associated with ribosomes in breast cancer cells.Biology direct · 2016Article
- Nucleolus-derived mediators in oncogenic stress response and activation of p53-dependent pathways.Histochemistry and cell biology · 2016Review
- Article
- Role of ribosomal protein mutations in tumor development (Review).International journal of oncology · 2016Review
- Requirement of Neuronal Ribosome Synthesis for Growth and Maintenance of the Dendritic Tree.The Journal of biological chemistry · 2016Article
- Ribosomal trafficking is reduced in Schwann cells following induction of myelination.Frontiers in cellular neuroscience · 2015Article
- Translational profiling through biotinylation of tagged ribosomes in zebrafish.Development (Cambridge, England) · 2014Article
- hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.PloS one · 2014Article
- Insights into the mechanism of ribosomal incorporation of mammalian L13a protein during ribosome biogenesis.Molecular and cellular biology · 2013Article
- Studies on the assembly characteristics of large subunit ribosomal proteins in S. cerevisae.PloS one · 2013Article
- Nucleolar trafficking of the mouse mammary tumor virus gag protein induced by interaction with ribosomal protein L9.Journal of virology · 2013Article
- Compartmentalization of mammalian pantothenate kinases.PloS one · 2012Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Considerable efforts are being undertaken to elucidate the processes of ribosome biogenesis. Although various preribosomal RNP complexes have been isolated and molecularly characterized, the order of ribosomal protein (r-protein) addition to the emerging ribosome subunits is largely unknown. Furthermore, the correlation between the ribosome assembly pathway and the structural organization of the dedicated ribosome factory, the nucleolus, is not well established. We have analyzed the nucleolar localization of several early binding r-proteins in human cells, applying various methods, including live-cell imaging and electron microscopy. We have located all examined r-proteins (S4, S6, S7, S9, S14, and L4) in the granular component (GC), which is the nucleolar region where later pre-ribosomal RNA (rRNA) processing steps take place. These results imply that early binding r-proteins do not assemble with nascent pre-rRNA transcripts in the dense fibrillar component (DFC), as is generally believed, and provide a link between r-protein assembly and the emergence of distinct granules at the DFC-GC interface.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.