ArticleInfection and immunity2007
Pathogen specificity and autoimmunity are distinct features of antigen-driven immune responses in neuroborreliosis.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity.The Journal of clinical investigation · 2015Trial
- Modified recombinant human IgG1-Fc is superior to natural intravenous immunoglobulin at inhibiting immune-mediated demyelination.Immunology · 2021Article
- A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis.Immunological reviews · 2020Review
- Detection of a Low Level and Heterogeneous B Cell Immune Response in Peripheral Blood of Acute Borreliosis Patients With High Throughput Sequencing.Frontiers in immunology · 2019Article
- ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody.Annals of clinical and translational neurology · 2017Article
- Dose-dependent inhibition of demyelination and microglia activation by IVIG.Annals of clinical and translational neurology · 2016Article
- Regulated Production of CXCL13 within the Central Nervous System.Journal of clinical & cellular immunology · 2016Article
- Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases.Cell reports · 2016Article
- Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis.Journal of autoimmunity · 2016Article
- Immune cell subtyping in the cerebrospinal fluid of patients with neurological diseases.Journal of neurology · 2014Article
- Does disease-irrelevant intrathecal synthesis in multiple sclerosis make sense in the light of tertiary lymphoid organs?Frontiers in neurology · 2014Review
- A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease.Arthritis and rheumatism · 2013Article
- Autoimmunity in Rheumatic Diseases Is Induced by Microbial Infections via Crossreactivity or Molecular Mimicry.Autoimmune diseases · 2012Article
- A case of relapsing-remitting neuroborreliosis? Challenges in the differential diagnosis of recurrent myelitis.Case reports in neurology · 2012Article
- Serum levels of interleukin 6 in recently hospitalized tick-borne encephalitis patients correlate with age, but not with disease outcome.Clinical and experimental immunology · 2008Article
- Targeting CXCL13 During Neuroinflammation.Advances in neuroimmune biologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuroborreliosis (NB) is a chronic infectious disease of the central nervous system (CNS) caused by a tick-borne spirochete, Borrelia burgdorferi. In addition to direct effects of the causative infectious agent, additional immunity-mediated mechanisms are thought to play a role in the CNS pathology of NB. In order to further understand the involvement of humoral immune mechanisms in NB, we dissected the intrathecal antibody responses down to the single-plasma-cell level. Starting with single-cell reverse transcription-PCR of fluorescence-activated cell sorter-sorted cerebrospinal fluid plasma cells from an NB patient, we identified expanded clones and resurrected the antigen specificity of their secreted antibodies through recombinant expression of the correctly paired immunoglobulin heavy- and light-chain genes as monoclonal antibodies (MAbs). As expected, we found specificity for the causative infectious agent, B. burgdorferi, among the clonally expanded plasma cell (cePC)-derived MAbs. However, from an independent cePC of the same patient, we could derive MAbs specific for human CNS myelin, without detectable cross-reactivity with B. burgdorferi antigens. While reactivity against B. burgdorferi is a known feature of humoral immune responses in NB, we show (i) that immune responses specific for self antigens may be a distinct feature of CNS infections independent of pathogen reactivity and (ii) that humoral autoimmunity in NB (since found in cePC) is the result of a truly antigen-driven immune response. Our findings indicate that in NB mechanisms may be at play that induce distinct immune responses specific for pathogen and self antigens independent from "molecular mimicry."
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.