ArticleNucleic acids research2007
Sp1 and Sp3 regulate basal transcription of the human APOBEC3G gene.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Interferon activates promoter of Nmi gene via interferon regulator factor-1.Molecular and cellular biochemistry · 2018Article
- The Cytidine Deaminase APOBEC3 Family Is Subject to Transcriptional Regulation by p53.Molecular cancer research : MCR · 2017Article
- Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Human retinal pigment epithelial cell proliferation by the combined stimulation of hydroquinone and advanced glycation end-products via up-regulation ofBiochemistry and biophysics reports · 2015Article
- Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all.Journal of molecular biology · 2014Review
- Prototype foamy virus Bet impairs the dimerization and cytosolic solubility of human APOBEC3G.Journal of virology · 2013Article
- Interplay between HIV-1 infection and host microRNAs.Nucleic acids research · 2012Article
- Transcriptional regulation of N-acetylglutamate synthase.PloS one · 2012Article
- Transcriptional and epigenetic regulation of KIAA1199 gene expression in human breast cancer.PloS one · 2012Article
- APOBEC3 proteins and genomic stability: the high cost of a good defense.Cell cycle (Georgetown, Tex.) · 2012Article
- Restriction of porcine endogenous retrovirus by porcine APOBEC3 cytidine deaminases.Journal of virology · 2011Article
- Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease.Retrovirology · 2011Article
- NFAT and IRF proteins regulate transcription of the anti-HIV gene, APOBEC3G.The Journal of biological chemistry · 2011Article
- Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes.The Journal of biological chemistry · 2010Article
- HIV-1 Vif binds to APOBEC3G mRNA and inhibits its translation.Nucleic acids research · 2010Article
- Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet.The Journal of biological chemistry · 2009Article
- Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cells.Gene · 2009Article
- Differences in APOBEC3G expression in CD4+ T helper lymphocyte subtypes modulate HIV-1 infectivity.PLoS pathogens · 2009Article
- The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals.BMC molecular biology · 2008Article
- Functions, structure, and read-through alternative splicing of feline APOBEC3 genes.Genome biology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
APOBEC3G (A3G), a member of the recently discovered family of human cytidine deaminases, is expressed in peripheral blood lymphocytes and has been shown to be active against HIV-1 and other retroviruses. To gain new insights into the transcriptional regulation of this restriction factor, we cloned and characterized the promoter region of A3G. Transcriptional start sites were identified by 5'-rapid amplification of cDNA ends analysis. Luciferase reporter assays demonstrated that a 1025 bp A3G promoter sequence (from -959 to +66 relative to the major transcriptional start site) displayed constitutive promoter activity. In T cells, the A3G promoter was not inducible by mitogenic stimulation, interferon treatment or expression of HIV-1 proteins. Using a series of 5' deletion promoter constructs in luciferase reporter assays, we identified a 180 bp region that was sufficient for full promoter activity. Transcriptional activity of this A3G core promoter was dependent on a GC-box (located at position -87/-78 relative to the major transcriptional start site) and was abolished after mutation of this DNA element. Electrophoretic mobility shift assays and chromatin immunoprecipitation assays demonstrated that the identified GC-box represented a binding site for the ubiquitous transcription factors specificity protein (Sp) 1 and Sp3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.