ArticleProceedings of the National Academy of Sciences of the United States of America2007
Nonlinear relaxation dynamics in elastic networks and design principles of molecular machines.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Dimensional reduction and adaptation-development-evolution relation in evolved biological systems.Biophysical reviews · 2024Review
- The Statistical Trends of Protein Evolution: A Lesson from AlphaFold Database.Molecular biology and evolution · 2022Article
- Detection of Single Molecules Using Stochastic Resonance of Bistable Oligomers.Nanomaterials (Basel, Switzerland) · 2020Article
- Allosteric communication in molecular machines via information exchange: what can be learned from dynamical modeling.Biophysical reviews · 2020Review
- Analyzing Fluctuation Properties in Protein Elastic Networks with Sequence-Specific and Distance-Dependent Interactions.Biomolecules · 2019Article
- Simple mechanics of protein machines.Journal of the Royal Society, Interface · 2019Article
- Coarse-Grained Protein Dynamics Studies Using Elastic Network Models.International journal of molecular sciences · 2018Review
- Designed Elastic Networks: Models of Complex Protein Machinery.International journal of molecular sciences · 2018Review
- High-speed atomic force microscopy and its future prospects.Biophysical reviews · 2018Review
- Deciphering Intrinsic Inter-subunit Couplings that Lead to Sequential Hydrolysis of FBiophysical journal · 2017Article
- Design of Elastic Networks with Evolutionary Optimized Long-Range Communication as Mechanical Models of Allosteric Proteins.Biophysical journal · 2017Article
- Analysis of an ATP-induced conformational transition of ABC transporter MsbA using a coarse-grained model.Biophysics and physicobiology · 2017Article
- Nonlinear network model analysis of vibrational energy transfer and localisation in the Fenna-Matthews-Olson complex.Scientific reports · 2016Article
- Fractal globules: a new approach to artificial molecular machines.Biophysical journal · 2014Article
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- Myosin-V as a mechanical sensor: an elastic network study.Biophysical journal · 2012Article
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- In silico investigation of conformational motions in superfamily 2 helicase proteins.PloS one · 2011Article
- Tracing entire operation cycles of molecular motor hepatitis C virus helicase in structurally resolved dynamical simulations.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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2 authors.
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Abstract
Analyzing nonlinear conformational relaxation dynamics in elastic networks corresponding to two classical motor proteins, we find that they respond by well defined internal mechanical motions to various initial deformations and that these motions are robust against external perturbations. We show that this behavior is not characteristic for random elastic networks. However, special network architectures with such properties can be designed by evolutionary optimization methods. Using them, an example of an artificial elastic network, operating as a cyclic machine powered by ligand binding, is constructed.
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