ArticleProceedings of the National Academy of Sciences of the United States of America2007
Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
- Chromosomal instability in cancer: sources, consequences and new therapeutic opportunities.Signal transduction and targeted therapy · 2026Review
- Review
- Exploring genome-transcriptome correlations in cancer.Biochemical Society transactions · 2025Review
- Centromeres in cancer: Unraveling the link between chromosomal instability and tumorigenesis.Medical oncology (Northwood, London, England) · 2024Review
- CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells.Cancer biology & therapy · 2023Article
- Gene dosage compensation: Origins, criteria to identify compensated genes, and mechanisms including sensor loops as an emerging systems-level property in cancer.Cancer medicine · 2023Review
- miR-18a expression correlates with ATM and p53 levels and poor prognosis in lymphomas.Journal of Cancer · 2023Article
- Suppression of Chromosome Instability Limits Acquired Drug Resistance.Molecular cancer therapeutics · 2022Article
- Mathematical modeling for mutator phenotype and clonal selection advantage in the risk analysis of lung cancer.Theory in biosciences = Theorie in den Biowissenschaften · 2022Article
- Chromosomal instability in adult-type diffuse gliomas.Acta neuropathologica communications · 2022Review
- Understanding Retinoblastoma Post-Translational Regulation for the Design of Targeted Cancer Therapies.Cancers · 2022Review
- The Dynamic Instability of the Aneuploid Genome.Frontiers in cell and developmental biology · 2022Review
- Article
- The unfolded protein response links tumor aneuploidy to local immune dysregulation.EMBO reports · 2021Article
- Suv420 enrichment at the centromere limits Aurora B localization and function.Journal of cell science · 2021Article
- CDKN2A Deletion in Melanoma Excludes T Cell Infiltration by Repressing Chemokine Expression in a Cell Cycle-Dependent Manner.Frontiers in oncology · 2021Article
- Insights into Hepatitis B Virus DNA Integration-55 Years after Virus Discovery.Innovation (Cambridge (Mass.)) · 2020Review
- Aneuploidy and gene expression: is there dosage compensation?Epigenomics · 2019Review
- Aneuploidy in yeast: Segregation error or adaptation mechanism?Yeast (Chichester, England) · 2019Article
- HNRNPL RestrainsCancers · 2019Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Chromosome instability and aneuploidy are hallmarks of cancer, but it is not clear how changes in the chromosomal content of a cell contribute to the malignant phenotype. Previously we have shown that we can readily isolate highly proliferative tumor cells and their revertants from highly invasive tumor cell populations, indicating how phenotypic shifting can contribute to malignant progression. Here we show that chromosome instability and changes in chromosome content occur with phenotypic switching. Further, we show that changes in the copy number of each chromosome quantitatively impose a proportional change in the chromosome transcriptome ratio. This correlation also applies to subchromosomal regions of derivative chromosomes. Importantly, we show that the changes in chromosome content and the transcriptome favor the expression of a large number of genes appropriate for the specific tumor phenotype. We conclude that chromosome instability generates the necessary chromosome diversity in the tumor cell populations and, therefore, the transcriptome diversity to allow for environment-facilitated clonal expansion and clonal evolution of tumor cell populations.
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