ArticleBiochemical and biophysical research communications2007
Regional differences in prostaglandin E2 and nitric oxide production in the knee meniscus in response to dynamic compression.
Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment byEvidence-based complementary and alternative medicine : eCAM · 2019Article
- The Pathobiology of the Meniscus: A Comparison Between the Human and Dog.Frontiers in veterinary science · 2018Review
- Mechanobiology of the meniscus.Journal of biomechanics · 2015Review
- In vivo cartilage strain increases following medial meniscal tear and correlates with synovial fluid matrix metalloproteinase activity.Journal of biomechanics · 2015Article
- Atomic force microscopy reveals regional variations in the micromechanical properties of the pericellular and extracellular matrices of the meniscus.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2013Article
- Response of cartilage and meniscus tissue explants to in vitro compressive overload.Osteoarthritis and cartilage · 2012Article
- Remodeling and repair of orthopedic tissue: role of mechanical loading and biologics.American journal of orthopedics (Belle Mead, N.J.) · 2010Review
- Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1.Osteoarthritis and cartilage · 2010Article
- Transfer of macroscale tissue strain to microscale cell regions in the deformed meniscus.Biophysical journal · 2008Article
- Integrative repair of the meniscus: lessons from in vitro studies.Biorheology · 2008Article
- Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients.Connective tissue researchArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Injury or loss of the knee meniscus is associated with altered joint stresses that lead to progressive joint degeneration. The goal of this study was to determine if dynamic mechanical compression influences the production of inflammatory mediators by meniscal cells. Dynamic compression increased prostaglandin E2 (PGE(2)) and nitric oxide (NO) production over a range of stress magnitudes (0.0125-0.5 MPa) in a manner that depended on stress magnitude and zone of tissue origin. Inner zone explants showed greater increases in PGE(2) and NO production as compared to outer zone explants. Meniscal tissue expressed NOS2 and NOS3 protein, but not NOS1. Mechanically induced NO production was blocked by NOS inhibitors, and the non-selective NOS inhibitor L-NMMA augmented PGE(2) production in the outer zone only. These findings suggest that the meniscus may serve as an intra-articular source of pro-inflammatory mediators, and that alterations in the magnitude or distribution of joint loading could significantly influence the production of these mediators in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.