Trial reportThe Journal of pediatrics2007
Interobserver reliability and accuracy of cranial ultrasound scanning interpretation in premature infants.
Trial report in The Journal of pediatrics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00016523 (Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Pooled it
- Pooled it
- Brain injury in the international multicenter randomized SafeBoosC phase II feasibility trial: cranial ultrasound and magnetic resonance imaging assessments.Pediatric research · 2016Trial
- Trial
- School Performance of Preterm-Born Children After Intraventricular Hemorrhage.JAMA network open · 2025Article
- Neonatal Neuroimaging Among Children Born Extremely Preterm and Motor Coordination Impairment at School-Age.The Journal of pediatrics · 2025Article
- Can deep learning classify cerebral ultrasound images for the detection of brain injury in very preterm infants?European radiology · 2025Article
- Intraventricular Hemorrhage and Survival, Multimorbidity, and Neurodevelopment.JAMA network open · 2025Article
- International Variation and Trends of Intraventricular Hemorrhage in Very Preterm Infants.Neonatology · 2025Article
- Fetal intracranial hemorrhage and infarct: Main sonographic and MRI characteristics: A review article.European journal of obstetrics & gynecology and reproductive biology: X · 2024Review
- Interobserver reliability between pediatric radiologists and residents in ultrasound evaluation of intraventricular hemorrhage in premature infants.World journal of radiology · 2022Article
- Normal variant residual germinal matrix in extremely premature infants: radiographic features and imaging pitfalls.Journal of ultrasound · 2022Review
- Rate of head ultrasound abnormalities at one month in very premature and extremely premature infants with normal initial screening ultrasound.Pediatric radiology · 2022Article
- Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm.Open medicine (Warsaw, Poland) · 2022Article
- Prenatal Evaluation of Intracranial Hemorrhage on Fetal MRI: A Retrospective Review.AJNR. American journal of neuroradiology · 2021Article
- Survival of Ventilated Extremely Premature Neonates With Severe Intraventricular Hemorrhage.Pediatrics · 2021Article
- Consensus Approach for Standardizing the Screening and Classification of Preterm Brain Injury Diagnosed With Cranial Ultrasound: A Canadian Perspective.Frontiers in pediatrics · 2021Article
- Risk factors and short-term complications of high-grade intraventricular hemorrhages in preterm neonates in training hospitals of Alborz.Iranian journal of child neurology · 2021Article
- Serious neonatal morbidities are associated with differences in DNA methylation among very preterm infants.Clinical epigenetics · 2020Article
- Additional value of advanced neurosonography and magnetic resonance imaging in fetuses at risk for brain damage.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2020Observational
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo assess interobserver reliability between 2 central readers of cranial ultrasound scanning (CUS) and accuracy of local, compared with central, interpretations. STUDY
designThe study was a retrospective analysis of CUS data from the National Institute of Child Health and Human Development (NICHD) trial of inhaled nitric oxide for premature infants. Interobserver reliability of 2 central readers was assessed with kappa or weighted kappa. Accuracy of local, compared with central, interpretations was assessed by using sensitivity and specificity.
resultsCUS from 326 infants had both central reader and local interpretations. Central reader agreement for grade 3/4 intraventricular hemorrhage (IVH), grade 3/4 IVH or periventricular leukomalacia (PVL), grade of IVH, and degree of ventriculomegaly was very good (kappa = 0.84, 0.81, 0.79, and 0.75, respectively). Agreement was poor for lower grade IVH and for PVL alone. Local interpretations were highly accurate for grade 3/4 IVH or PVL (sensitivity, 87%-90%; specificity, 92%-93%), but sensitivity was poor-to-fair for grade 1/2 IVH (48%-68%) and PVL (20%-44%).
conclusionsOur findings demonstrate reliability and accuracy of highly unfavorable CUS findings, but suggest caution when interpreting mild to moderate IVH or white matter injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.