ArticleClinical drug investigation2004
Depression during Pregnancy : Overview of Clinical Factors.
Article in Clinical drug investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it, 313 citations in OpenAlex.
- Interventions to treat mental disorders during pregnancy: A systematic review and multiple treatment meta-analysis.PloS one · 2017Pooled it
- Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 6. Special Populations: Youth, Women, and the Elderly.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2016Pooled it
- Interventions (other than pharmacological, psychosocial or psychological) for treating antenatal depression.The Cochrane database of systematic reviews · 2013Pooled it
- A meta-analysis of treatments for perinatal depression.Clinical psychology review · 2011Pooled it
- Promoting psychological resilience during the perinatal period with a digital tool (the HealthyMoms4MentalHealth-app): a study protocol for a randomised controlled trial in Sweden.BMC public health · 2026Article
- Assessment of emotional status and risk factors in early pregnancy using multidimensional data: a cross-sectional study.BMC pregnancy and childbirth · 2025Article
- Personal Growth Among Pregnant Women During War: The Role of Optimism and Meaning in Life.International journal of psychology : Journal international de psychologie · 2025Article
- Trajectories of changes in oxytocin and vasopressin before, during, and after mother-infant interaction: a descriptive study of mothers and infants affected by postpartum depression.Frontiers in psychiatry · 2025Article
- Understanding the relationship between childhood emotional abuse and neglect and psychological distress in pregnant women: the role of prenatal attachment.BMC psychology · 2024Article
- Maternal Stress Mediates Association of Infant Socioemotional Development with Perinatal Mental Health in Socioeconomically Vulnerable Peruvian Settings.International journal of environmental research and public health · 2024Article
- Investigating heart rate variability measures during pregnancy as predictors of postpartum depression and anxiety: an exploratory study.Translational psychiatry · 2024Article
- Risk factors of positive depression screening during the third trimester of pregnancy in a Chinese tertiary hospital: a cross-sectional study.BMC psychiatry · 2023Article
- Effects of Recreational Therapy and 3D Ultrasonography for High-Risk Pregnancies on Psychological Well-Being during Hospitalization and in the Puerperal Phase.Journal of clinical medicine · 2023Article
- Maternal Diet Quality and Prenatal Depressive Symptoms: The Moderating Role of Economic Well-Being.Nutrients · 2023Article
- Integrating Peripartum Mental Health Education into the Psychiatry Clerkship: a Multimodal Approach.Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry · 2022Article
- Depression and quality of life among pregnant women in first and third trimesters in Abeokuta: A comparative study.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2022Article
- Neuroactive steroids and depression in early pregnancy.Psychoneuroendocrinology · 2021Article
- Changes in severity of depression and borderline personality disorder symptoms from pregnancy to three years postpartum in adolescent mothers.Journal of affective disorders · 2021Article
- The magnitude and determinants of antepartum depression among women attending antenatal clinic at a tertiary hospital, in Mwanza Tanzania: a cross-sectional study.The Pan African medical journal · 2021Article
- Association Between Perceived Stress and Prenatal Depressive Symptoms: Moderating Effect of Social Support.Journal of multidisciplinary healthcare · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression during pregnancy is common, affecting an estimated 20% of women. However, conflicting data exist concerning the outcomes of this disorder. Thus, we reviewed studies that presented evidence for the use of antidepressants and those that examined untreated depression during the gestational period, in terms of clinical and epidemiological aspects.Observational studies have provided reassuring evidence of the safety of antidepressant use during pregnancy. However, due to the reluctance of healthcare providers to prescribe and patients to take medication during the obstetric period, approximately three-quarters of those diagnosed with depression remain untreated. Furthermore, healthcare providers apparently do not recognise the disorder in up to 50% of pregnant women who experience depression. Increased antidepressant dosing during pregnancy may be required to maintain euthymia; however, guidelines for effective dosing levels are absent. Consequently, many patients remain inadequately treated. Substantial maternal and fetal morbidity including substance abuse, functional impairment, increased risk of postnatal depression, and poor pregnancy outcomes have resulted from untreated depression.The consequences of those outcomes are likely to be associated with substantial clinical, social and economic burdens. An incidence-based assessment of the consequences of prenatal depression would be useful in order to: (i) establish the impact on the quality of life of these patients and their families; (ii) assess the associated economic burden on individual families and the healthcare system; and (iii) to provide epidemiological data to enable the provision of suitable management strategies for these patients.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.