ReviewHeart failure reviews2007
Cardioprotective actions of peptide hormones in myocardial ischemia.
Review in Heart failure reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 69 citations in OpenAlex.
- A biodegradable, microstructured, electroconductive and nano-integrated drug eluting patch (MENDEP) for myocardial tissue engineering.Bioactive materials · 2025Article
- PPAR Alpha Activation by Clofibrate Alleviates Ischemia/Reperfusion Injury in Metabolic Syndrome Rats by Decreasing Cardiac Inflammation and Remodeling and by Regulating the Atrial Natriuretic Peptide Compensatory Response.International journal of molecular sciences · 2023Article
- Article
- Functional modulation of sarcolemmal KAmerican journal of physiology. Cell physiology · 2020Article
- PDRPS7 protects cardiac cells from hypoxia/reoxygenation injury through inactivation of JNKs.FEBS open bio · 2020Article
- C-type natriuretic peptide co-ordinates cardiac structure and function.European heart journal · 2020Article
- Preconditioning strategies to prevent acute kidney injury.F1000Research · 2020Review
- C-Type Natriuretic Peptide (CNP) Inhibition of Interferon-γ-Mediated Gene Expression in Human Endothelial Cells In Vitro.Biosensors · 2018Article
- Observational
- Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy.PLoS biology · 2017Article
- Cardiomyocyte mitochondria as targets of humoral factors released by remote ischemic preconditioning.Archives of medical science : AMS · 2017Article
- Simvastatin Promotes Cardiac Myocyte Relaxation in Association with Phosphorylation of Troponin I.Frontiers in pharmacology · 2017Article
- Cardiac-Secreted Factors as Peripheral Metabolic Regulators and Potential Disease Biomarkers.Journal of the American Heart Association · 2016Review
- Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.The Journal of biological chemistry · 2016Article
- Article
- Induction of cardioprotection by small netrin-1-derived peptides.American journal of physiology. Cell physiology · 2015Article
- Extracellular signalling molecules in the ischaemic/reperfused heart - druggable and translatable for cardioprotection?British journal of pharmacology · 2015Review
- Natriuretic peptides modulate ATP-sensitive K(+) channels in rat ventricular cardiomyocytes.Basic research in cardiology · 2014Article
- Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models.Circulation · 2012Article
- DPP4 deficiency preserves cardiac function via GLP-1 signaling in rats subjected to myocardial ischemia/reperfusion.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The myocardium represents a major source of several families of peptide hormones under normal physiological conditions and the plasma concentrations of many of these "cardiac peptides" (or related pro-peptide fragments) are substantially augmented in many cardiac disease states. In addition to well-characterised endocrine functions of several of the cardiac peptides, pleiotropic functions within the myocardium and the coronary vasculature represent a significant aspect of their actions in health and disease. Here, we focus specifically on the cardioprotective roles of four major peptide families in myocardial ischemia and reperfusion: adrenomedullin, kinins, natriuretic peptides and the urocortins. The patterns of early release of all these peptides are consistent with roles as autacoid cardioprotective mediators. Clinical and experimental research indicates the early release and upregulation of many of these peptides by acute ischemia and there is a convincing body of evidence showing that exogenously administered adrenomedullin, bradykinin, ANP, BNP, CNP and urocortins are all markedly protective against experimental myocardial ischemia-reperfusion injury through a conserved series of cytoprotective signal transduction pathways. Intriguingly, all the peptides examined so far have the potential to salvage against infarction when administered specifically during early reperfusion. Thus, the myocardial secretion of peptide hormones likely represents an early protective response to ischemia. Further work is required to explore the potential therapeutic manipulation of these peptides in acute coronary syndromes and their promise as biomarkers of acute myocardial ischemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.