ArticleMolecular medicine (Cambridge, Mass.)
Blue laser light increases perfusion of a skin flap via release of nitric oxide from hemoglobin.
Article in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Photobiomodulation Therapy on Oxidative Stress in Muscle Injury Animal Models: A Systematic Review.Oxidative medicine and cellular longevity · 2017Pooled it
- A feasibility study of a novel low-level light therapy for digital ulcers in systemic sclerosis.The Journal of dermatological treatment · 2019Trial
- Photobiomodulation for hormone therapy-induced sexual dysfunction in women with breast cancer: a prospective quasi-experimental clinical study with a parallel observational group.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Nonionizing Electromagnetic Irradiations; Biological Interactions, Human Safety.Journal of biomedical physics & engineering · 2023Review
- Wavelength-Dependent Effects of Photobiomodulation for Wound Care in Diabetic Wounds.International journal of molecular sciences · 2023Article
- Blue Light in Dermatology.Life (Basel, Switzerland) · 2021Review
- Overview of Artificial Intelligence Applications in Chinese Medicine Therapy.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Photobiomodulation (PBM) promotes angiogenesis in-vitro and in chick embryo chorioallantoic membrane model.Scientific reports · 2018Article
- Computational Structural Biology ofFrontiers in oncology · 2018Review
- Effects of Laser Radiation on Mitochondria and Mitochondrial Proteins Subjected to Nitric Oxide.Frontiers in medicine · 2018Review
- The impact of wavelengths of LED light-therapy on endothelial cells.Scientific reports · 2017Article
- The Effect of Combination of Red, Infrared and Blue Wavelengths of Low-Level Laser on Reduction of Abdominal Girth: A Before-After Case Series.Journal of lasers in medical sciences · 2017Article
- Are the mitochondrial respiratory complexes blocked by NO the targets for the laser and LED therapy?Lasers in medical science · 2015Article
- Blue or red: which intravascular laser light has more effects in diabetic patients?Lasers in medical science · 2015Article
- Blue-violet light irradiation dose dependently decreases carotenoids in human skin, which indicates the generation of free radicals.Oxidative medicine and cellular longevity · 2015Article
- Effects of low-level laser therapy on mitochondrial respiration and nitrosyl complex content.Lasers in medical science · 2014Article
- Low-level laser therapy and light-emitting diode effects in the secretion of neuropeptides SP and CGRP in rat skin.Lasers in medical science · 2014Article
- A metabolomic study on the effect of intravascular laser blood irradiation on type 2 diabetic patients.Lasers in medical science · 2013Article
- Effects of laser and LED radiation on mitochondrial respiration in experimental endotoxic shock.Lasers in medical science · 2013Article
- Yes, there is deqi sensation in laser acupuncture.Evidence-based complementary and alternative medicine : eCAM · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has recently been shown that nitrosyl complexes of hemoglobin (NO-Hb) are sensitive to low-level blue laser irradiation, suggesting that laser irradiation can facilitate the release of biologically active nitric oxide (NO), which can affect tissue perfusion. The aim of this study was to evaluate the therapeutic value of blue laser irradiation for local tissue perfusion after surgical intervention. Blood was withdrawn from a rat, exposed to NO and infused back to the same rat or used for in vitro experiments. In vitro, an increase of NO-Hb levels (electron paramagnetic resonance spectroscopy) up to 15 microM in rat blood did not result in the release of detectable amounts of NO (NO selective electrode). Blue laser irradiation of NO-Hb in blood caused decomposition of NO-Hb complexes and release of free NO. Systemic infusion of NO-Hb in rats affected neither systemic circulation (mean arterial pressure) nor local tissue perfusion (Doppler blood flow imaging system). In contrast, a clear enhancement of local tissue perfusion was observed in epigastric flap when elevated NO-Hb levels in blood were combined with local He-Cd laser irradiation focused on the left epigastric artery. The enhancement of regional tissue perfusion was not accompanied by any detectable changes in systemic circulation. This study demonstrates that blue laser irradiation improves local tissue perfusion in a controlled manner stimulating NO release from NO-Hb complexes.
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