ArticleMolecular vision2007
Increased oxidative stress in diabetes regulates activation of a small molecular weight G-protein, H-Ras, in the retina.
Article in Molecular vision, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Identification of Potentially Functional Circular RNA/Long Noncoding RNA-MicroRNA-mRNA Regulatory Networks Associated with Vascular Injury in Type 2 Diabetes Mellitus by Integrated Microarray Analysis.Journal of diabetes research · 2023Article
- Serum Exosomal Circular RNA Expression Profile and Regulative Role in Proliferative Diabetic Retinopathy.Frontiers in genetics · 2021Article
- Heat Shock Proteins in Oxidative Stress and Ischemia/Reperfusion Injury and Benefits from Physical Exercises: A Review to the Current Knowledge.Oxidative medicine and cellular longevity · 2021Review
- Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy.Oxidative medicine and cellular longevity · 2017Review
- Acute and Chronic Hyperglycemia Elicit JIP1/JNK-Mediated Endothelial Vasodilator Dysfunction of Retinal Arterioles.Investigative ophthalmology & visual science · 2016Article
- Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy.Investigative ophthalmology & visual science · 2014Article
- miR-375 and miR-30d in the effect of chromium-containing Chinese medicine moderating glucose metabolism.Journal of diabetes research · 2014Article
- Astaxanthin attenuates the apoptosis of retinal ganglion cells in db/db mice by inhibition of oxidative stress.Marine drugs · 2013Article
- Chromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnostics.Infectious disorders drug targets · 2012Article
- Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9.Journal of cellular physiology · 2012Article
- Mitochondrial biogenesis and the development of diabetic retinopathy.Free radical biology & medicine · 2011Article
- Inflammation in diabetic retinopathy.Progress in retinal and eye research · 2011Review
- Chromium-picolinate therapy in diabetes care: molecular and subcellular profiling revealed a necessity for individual outcome prediction, personalised treatment algorithms and new guidelines.Infectious disorders drug targets · 2011Article
- The role of Raf-1 kinase in diabetic retinopathy.Expert opinion on therapeutic targets · 2011Review
- Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction.Laboratory investigation; a journal of technical methods and pathology · 2010Article
- Translocation of H-Ras and its implications in the development of diabetic retinopathy.Biochemical and biophysical research communications · 2009Article
- Reactive oxygen species: a double-edged sword in oncogenesis.World journal of gastroenterology · 2009Review
- Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling.Toxicology · 2009Article
- Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways.Molecular vision · 2009Article
- Molecular mechanisms and clinical implications of reversible protein S-glutathionylation.Antioxidants & redox signaling · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIncreased superoxide levels are implicated in the pathogenesis of diabetic retinopathy. We have shown that functional activation of a small molecular weight G-protein, H-Ras, is one of the signaling steps involved in glucose-induced apoptosis of retinal capillary cells. The goal of this study was to elucidate the mechanism(s) by which oxidative stress could result in the activation of H-Ras in diabetes.
methodsExperiments were performed in isolated retinal endothelial cells that were treated with H(2)O(2), or the cells in which glucose-induced superoxide accumulation was inhibited either by superoxide dismutase mimetic (MnTBAP) or by overexpressing mitochondrial superoxide dismutase (MnSOD). The in vitro experiments were complemented with in vivo experiments using the retina from mice overexpressing MnSOD.
resultsH(2)O(2) activated H-Ras and its downstream signaling pathway, including Raf-1 and phosphorylation of p38 (p-p38) MAP kinase. Inhibition of superoxide significantly attenuated glucose-induced activation of H-Ras, Raf-1 and p-p38 MAP kinase. Overexpression of MnSOD in mice prevented diabetes-induced activation of both H-Ras and p-p38 MAP kinase.
conclusionsOur results clearly indicate that the activation of H-Ras and its downstream signaling pathway in the retina and its vasculature could be under the control of superoxide, and H-Ras activation in diabetes can be prevented by inhibiting superoxide accumulation.
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Identifiers
17515880PMC2669505W1548788344What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.