ArticlePediatric research2007
In vitro transdifferentiation of human fetal type II cells toward a type I-like cell.
Article in Pediatric research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing.bioRxiv : the preprint server for biology · 2025Article
- Targeting USP11 counteractsTheranostics · 2025Article
- Multicompartment duct platform to study epithelial-endothelial crosstalk associated with lung adenocarcinoma.APL bioengineering · 2024Article
- Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants.Stem cell reports · 2024Article
- Human alveolar hydrogels promote morphological and transcriptional differentiation in iPSC-derived alveolar type 2 epithelial cells.Scientific reports · 2023Article
- A Monoclonal Human Alveolar Epithelial Cell Line ("Arlo") with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Development of human alveolar epithelial cell models to study distal lung biology and disease.iScience · 2022Article
- Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease.Cell reports · 2021Article
- miR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation.ERJ open research · 2019Article
- Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.American journal of respiratory cell and molecular biology · 2018Article
- Long-Term Culture of Distal Airway Epithelial Cells Allows Differentiation Towards Alveolar Epithelial Cells Suited for Influenza Virus Studies.EBioMedicine · 2018Article
- Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.Cell stem cell · 2017Article
- When Is an Alveolar Type 2 Cell an Alveolar Type 2 Cell? A Conundrum for Lung Stem Cell Biology and Regenerative Medicine.American journal of respiratory cell and molecular biology · 2017Review
- Differential Regulation of Gene Expression of Alveolar Epithelial Cell Markers in Human Lung Adenocarcinoma-Derived A549 Clones.Stem cells international · 2015Article
- Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Regulated gene expression in cultured type II cells of adult human lung.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- The Rho pathway mediates transition to an alveolar type I cell phenotype during static stretch of alveolar type II cells.Pediatric research · 2010Article
- Transient in utero disruption of cystic fibrosis transmembrane conductance regulator causes phenotypic changes in alveolar type II cells in adult rats.BMC cell biology · 2009Article
- Immortalization of human alveolar epithelial cells to investigate nanoparticle uptake.American journal of respiratory cell and molecular biology · 2008Article
- Pepsinogen C proteolytic processing of surfactant protein B.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
For alveolar type I cells, phenotype plasticity and physiology other than gas exchange await further clarification due to in vitro study difficulties in isolating and maintaining type I cells in primary culture. Using an established in vitro model of human fetal type II cells, in which the type II phenotype is induced and maintained by adding hormones, we assessed for transdifferentiation in culture toward a type I-like cell with hormone removal for up to 144 h, followed by electron microscopy, permeability studies, and RNA and protein analysis. Hormone withdrawal resulted in diminished type II cell characteristics, including decreased microvilli, lamellar bodies, and type II cell marker RNA and protein. There was a simultaneous increase in type I characteristics, including increased epithelial cell barrier function indicative of a tight monolayer and increased type I cell marker RNA and protein. Our results indicate that hormone removal from cultured human fetal type II cells results in transdifferentiation toward a type I-like cell. This model will be useful for continued in vitro studies of human fetal alveolar epithelial cell differentiation and phenotype plasticity.
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