ArticleProteomics2007
Identification of biomarkers associated with the development of hepatocellular carcinoma in CuZn superoxide dismutase deficient mice.
Article in Proteomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Transcriptomic Analysis of the Liver Redox Response During Food-Anticipatory Activity Under a Time-Restricted Feeding Protocol in Rats.Antioxidants (Basel, Switzerland) · 2025Article
- Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2023Article
- Regucalcin Is a Potential Regulator in Human Cancer: Aiming to Expand into Cancer Therapy.Cancers · 2023Review
- Synthesis and evaluation of 2,4,5-trisubstitutedthiazoles as carbonic anhydrase-III inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Fermentable fiber-induced hepatocellular carcinoma in mice recapitulates gene signatures found in human liver cancer.PloS one · 2020Article
- The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage.Aging · 2019Article
- Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure.Oxidative medicine and cellular longevity · 2018Article
- Expression of liver fatty acid binding protein in hepatocellular carcinoma.Human pathology · 2016Article
- Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice.Mechanisms of ageing and development · 2016Article
- iTRAQ-based proteomic analysis of hepatic tissues from patients with hepatitis B virus-induced acute-on-chronic liver failure.Experimental and therapeutic medicine · 2015Article
- Involvement of regucalcin as a suppressor protein in human carcinogenesis: insight into the gene therapy.Journal of cancer research and clinical oncology · 2015Review
- Regucalcin as a potential biomarker for metabolic and neuronal diseases.Molecular and cellular biochemistry · 2014Review
- Manganese superoxide dismutase in cancer prevention.Antioxidants & redox signaling · 2014Review
- The diverse roles of calcium-binding protein regucalcin in cell biology: from tissue expression and signalling to disease.Cellular and molecular life sciences : CMLS · 2014Review
- Dietary restriction attenuates the accelerated aging phenotype of Sod1(-/-) mice.Free radical biology & medicine · 2013Article
- Suppressive role of regucalcin in liver cell proliferation: involvement in carcinogenesis.Cell proliferation · 2013Review
- Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4.Arthritis research & therapy · 2012Article
- Enhanced peptide quantification using spectral count clustering and cluster abundance.BMC bioinformatics · 2011Article
- Identification of cytokeratin 18 as a biomarker of mouse and human hepatosplenic schistosomiasis.Infection and immunity · 2011Article
- Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.Journal of proteomics · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
To identify biomarkers associated with the development of hepatocellular carcinoma (HCC) in CuZn superoxide dismutase (CuZnSOD, Sod1) deficient mice, 2-DE followed by MS analysis was carried out with liver samples obtained from 18-month-old Sod1-/- and +/+ mice. The intracellular Ca binding protein, regucalcin (RGN), showed a divergent alteration in Sod1-/- samples. Whereas elevated RGN levels were observed in -/- samples with no obvious neoplastic changes, marked reduction in RGN was observed in -/- samples with fully developed HCC. GST mu1 (GSTM1), on the other hand, showed a significant increase only in the neoplastic regions obtained from Sod1-/- livers. No change in GSTM1 was observed in the surrounding normal tissues. Marked reduction was observed in two intracellular lipid transporters, fatty acid binding protein 1 (FABP1) and major urinary protein 11 and 8 (MUP 11&8), in Sod1-/- samples. Analysis of additional samples at 18-22 months of age showed a three-fold increase in enolase activities in Sod1-/- livers. Consistent with previous findings, carbonic anhydrase 3 (CAIII) levels were significantly reduced in Sod1-/- samples, and immunohistochemical analysis revealed that the reduction was not homogenous throughout the lobular structure in the liver.
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Registered trials
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