ReviewJournal of neural transmission (Vienna, Austria : 1996)2007
Which perspectives can endophenotypes and biological markers offer in the early recognition of schizophrenia?
Review in Journal of neural transmission (Vienna, Austria : 1996), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of neurological soft signs in relatives of people with schizophrenia.BMC psychiatry · 2011Pooled it
- Predicting the diagnosis of various mental disorders in a mixed cohort using blood-based multi-protein model: a machine learning approach.European archives of psychiatry and clinical neuroscience · 2023Article
- Association of Transferrin Gene Polymorphism with Cognitive Deficits and Psychiatric Symptoms in Patients with Chronic Schizophrenia.Journal of clinical medicine · 2022Article
- Use of cognitive event-related potentials in the management of psychiatric disorders: Towards an individual follow-up and multi-component clinical approach.World journal of psychiatry · 2021Review
- Frontal brain activity in individuals at risk for schizophrenic psychosis and bipolar disorder during the emotional Stroop task - an fNIRS study.NeuroImage. Clinical · 2020Article
- Neurophysiological Biomarkers in Schizophrenia-P50, Mismatch Negativity, and TMS-EMG and TMS-EEG.Frontiers in psychiatry · 2020Review
- Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders.Scientific reports · 2017Article
- Fetal programming of schizophrenia: select mechanisms.Neuroscience and biobehavioral reviews · 2015Review
- Transition to adulthood: the critical period for pre-emptive, disease-modifying care for schizophrenia and related disorders.Schizophrenia bulletin · 2011Review
- Clinical staging in the pathophysiology of psychotic and affective disorders: facilitation of prognosis and treatment.Neurotoxicity research · 2010Review
- Premorbid cognitive deficits in young relatives of schizophrenia patients.Frontiers in human neuroscience · 2010Article
- Schizophrenia genomics and proteomics: are we any closer to biomarker discovery?Behavioral and brain functions : BBF · 2009Article
- Neuroimaging in psychiatry: from bench to bedside.Frontiers in human neuroscience · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early recognition of schizophrenia seems crucial; various studies relate a longer duration-of-untreated-psychosis to a worse prognosis. We give an overview over common psychopathological early recognition instruments (BSABS, CAARMS, SIPS, IRAOS, ERIraos). However, many clinical symptoms of prodromal schizophrenia stages are not sufficiently specific. Thus we review recent contributions of neuroimaging and electrophysiological as well as genetic studies: which new diagnostic perspectives offer endophenotypes (such as P300, P50 sensory gating, MMN, smooth pursuit eye movements; indicating a specific genetic vulnerability) together with a better understanding of schizophrenic pathophysiology (state-dependent biological markers, e.g. aggravated motor neurological soft signs during psychosis) in prodromal schizophrenia when still ambiguous clinical symptoms are present. Several examples (e.g. from COMT polymorphisms to working memory deficits) illustrate more specific underlying neuronal mechanisms behind behavioural symptoms. This way, a characteristic pattern of disturbed cerebral maturation might be distinguished in order to complement clinical instruments of early schizophrenia detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.