ArticleMammalian genome : official journal of the International Mammalian Genome Society2007
A growth QTL (Pbwg1) region of mouse chromosome 2 contains closely linked loci affecting growth and body composition.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 23 citations in OpenAlex.
- Genetics of murine type 2 diabetes and comorbidities.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- QTL Mapping for Age-Related Eye Pigmentation in the Pink-Eyed Dilution Castaneus Mutant Mouse.Genes · 2022Article
- Mapping QTLs for Breast Muscle Weight in an FLife (Basel, Switzerland) · 2021Article
- Genetic identification of Ly75 as a novel quantitative trait gene for resistance to obesity in mice.Scientific reports · 2018Article
- A Strategy for Identifying Quantitative Trait Genes Using Gene Expression Analysis and Causal Analysis.Genes · 2017Review
- Article
- Body Composition QTLs Identified in Intercross Populations Are Reproducible in Consomic Mouse Strains.PloS one · 2015Article
- Fine mapping reveals that promotion susceptibility locus 1 (Psl1) is a compound locus with multiple genes that modify susceptibility to skin tumor development.G3 (Bethesda, Md.) · 2014Article
- Article
- Wild mice as bountiful resources of novel genetic variants for quantitative traits.Current genomics · 2013Article
- Subcongenic analysis of tabw2 obesity QTL on mouse chromosome 6.BMC genetics · 2012Article
- Article
- Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Article
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5 authors at 1 institution in 1 country.
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Abstract
Previous QTL studies have identified 24 QTLs for body weight and growth from 3 to 10 weeks after birth in an intersubspecific backcross mouse population between C57BL/6J and wild Mus musculus castaneus that has 60% of the body size of C57BL/6J. The castaneus allele at the most potent QTL (Pbwg1) on proximal chromosome 2 retards growth. In this study we have developed a congenic strain with a 44.1-Mb interval containing the castaneus allele at Pbwg1 by recurrent backcrossing to C57BL/6J. The congenic mouse developed was characterized by significantly higher body weight gain between 1 and 3 weeks of age and lower weight of white fat pads at 10 weeks of age than C57BL/6J. However, no clear difference in body weight at 1-10 weeks of age was observed between congenic and C57BL/6J strains. QTL analysis with 269 F(2) mice between the two strains did not identify any QTLs for body weight at 1, 3, 6, and 10 weeks of age, but it discovered eight closely linked QTLs affecting body weight gain from 1 to 3 weeks of age, lean body weight, weight of white fat pads, and body length within the Pbwg1 region. The castaneus alleles at all fat pad QTLs reduced the phenotypes, whereas at the remaining growth and body composition QTLs, they increased the trait values. These results illustrate that Pbwg1, which initially appeared to be a single locus, was resolved into several loci with opposite effects on the composition traits of overall body weight. This gives a reason for the loss of the Pbwg1 effect found in the original backcross population.
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