ArticleEukaryotic cell2007
Genomic and population analyses of the mating type loci in Coccidioides species reveal evidence for sexual reproduction and gene acquisition.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 83 citations in OpenAlex.
- Article
- Predicting Valley Fever Outbreaks: Novel Mechanistic Models Incorporating Climate and Ecological Interactions.bioRxiv : the preprint server for biology · 2026Article
- Article
- Hiding in plain sight: Genome-wide recombination and a dynamic accessory genome drive diversity inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Love in the time of climate change: A review of sexual reproduction in the order Onygenales.Fungal genetics and biology : FG & B · 2023Review
- Coccidioides Species: A Review of Basic Research: 2022.Journal of fungi (Basel, Switzerland) · 2022Review
- Genetic Networks That Govern Sexual Reproduction in the Pezizomycotina.Microbiology and molecular biology reviews : MMBR · 2021Review
- Mating Systems in True Morels (Microbiology and molecular biology reviews : MMBR · 2021Review
- The Plot Thickens: Haploid and Triploid-Like Thalli, Hybridization, and Biased Mating Type Ratios inFrontiers in fungal biology · 2021Article
- Frequency of the Mating-Type (MAT1) in Histoplasma capsulatum Isolates from Buenos Aires, Argentina.Mycopathologia · 2020Article
- The mysterious desert dwellers: Coccidioides immitis and Coccidioides posadasii, causative fungal agents of coccidioidomycosis.Virulence · 2019Review
- Article
- Analysis of Transposable Elements in Coccidioides Species.Journal of fungi (Basel, Switzerland) · 2018Article
- Sex and the Imperfect Fungi.Microbiology spectrum · 2017Review
- Unconventional Recombination in the Mating Type Locus of Heterothallic Apple Canker PathogenG3 (Bethesda, Md.) · 2017Article
- Exploring the genomic diversity of black yeasts and relatives (Studies in mycology · 2017Article
- The habitat of Coccidioides spp. and the role of animals as reservoirs and disseminators in nature.BMC infectious diseases · 2016Review
- Clonal reproduction in fungi.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Evolutionary Perspectives on Human Fungal Pathogens.Cold Spring Harbor perspectives in medicine · 2014Review
- Valley fever: danger lurking in a dust cloud.Microbes and infection · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Coccidioides species, the fungi responsible for the valley fever disease, are known to reproduce asexually through the production of arthroconidia that are the infectious propagules. The possible role of sexual reproduction in the survival and dispersal of these pathogens is unexplored. To determine the potential for mating of Coccidioides, we analyzed genome sequences and identified mating type loci characteristic of heterothallic ascomycetes. Coccidioides strains contain either a MAT1-1 or a MAT1-2 idiomorph, which is 8.1 or 9 kb in length, respectively, the longest reported for any ascomycete species. These idiomorphs contain four or five genes, respectively, more than are present in the MAT loci of most ascomycetes. Along with their cDNA structures, we determined that all genes in the MAT loci are transcribed. Two genes frequently found in common sequences flanking MAT idiomorphs, APN2 and COX13, are within the MAT loci in Coccidioides, but the MAT1-1 and MAT1-2 copies have diverged dramatically from each other. Data indicate that the acquisition of these genes in the MAT loci occurred prior to the separation of Coccidioides from Uncinocarpus reesii. An analysis of 436 Coccidioides isolates from patients and the environment indicates that in both Coccidioides immitis and C. posadasii, there is a 1:1 distribution of MAT loci, as would be expected for sexually reproducing species. In addition, an analysis of isolates obtained from 11 soil samples demonstrated that at three sampling sites, strains of both mating types were present, indicating that compatible strains were in close proximity in the environment.
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