ArticleJournal of medical genetics2007
Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment.
Article in Journal of medical genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Salt-inducible kinase 3, SIK3, is a new gene associated with hearing.Human molecular genetics · 2014Pooled it
- The Role and Research Progress of Mitochondria in Sensorineural Hearing Loss.Molecular neurobiology · 2025Review
- Unveiling the Role of Oxidative Stress in Cochlear Hair Cell Death: Prospective Phytochemical Therapeutics against Sensorineural Hearing Loss.International journal of molecular sciences · 2024Review
- The emerging roles and therapeutic implications of immunosenescence-mediated inflammaging in age-related hearing loss.American journal of stem cells · 2024Review
- Cochlear detoxification: Role of alpha class glutathione transferases in protection against oxidative lipid damage, ototoxicity, and cochlear aging.Hearing research · 2021Review
- Age-Related Changes in the Cochlea and Vestibule: Shared Patterns and Processes.Frontiers in neuroscience · 2021Review
- Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss.NPJ aging and mechanisms of disease · 2020Article
- Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- CYP1A1 and GSTs common gene variations and presbycusis risk: a genetic association analysis and a bioinformatics approach.Environmental science and pollution research international · 2020Article
- Synergistic effect of smoking on age-related hearing loss in patients with diabetes.Scientific reports · 2020Article
- Pathology and mechanisms of cochlear aging.Journal of neuroscience research · 2020Review
- Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice.Experimental gerontology · 2020Article
- Presbycusis: An Update on Cochlear Mechanisms and Therapies.Journal of clinical medicine · 2020Review
- Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy.Neural plasticity · 2020Review
- Age-Related Hearing Impairment Associated NAT2, GRM7, GRHL2 Susceptibility Gene Polymorphisms and Haplotypes in Roma and Hungarian Populations.Pathology oncology research : POR · 2019Article
- Age-Related Hearing Loss.Cold Spring Harbor perspectives in medicine · 2019Review
- Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss.eLife · 2019Article
- Impact of Aging on the Auditory System and Related Cognitive Functions: A Narrative Review.Frontiers in neuroscience · 2018Review
- Association of TMTC2 With Human Nonsyndromic Sensorineural Hearing Loss.JAMA otolaryngology-- head & neck surgery · 2016Article
- The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
Corrections and comments
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Authors and funding
33 authors at 11 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAge-related hearing impairment (ARHI) is the most common sensory impairment in older people, affecting 50% of those aged 80 years. The proportion of older people is increasing in the general population, and as a consequence, the number of people affected with ARHI is growing. ARHI is a complex disorder, with both environmental and genetic factors contributing to the disease. The first studies to elucidate these genetic factors were recently performed, resulting in the identification of the first two susceptibility genes for ARHI, NAT2 and KCNQ4.
methodsIn the present study, the association between ARHI and polymorphisms in genes that contribute to the defence against reactive oxygen species, including GSTT1, GSTM1 and NAT2, was tested. Samples originated from seven different countries and were combined into two test population samples, the general European population and the Finnish population. Two distinct phenotypes for ARHI were studied, Z(low) and Z(high), representing hearing in the low and high frequencies, respectively. Statistical analysis was performed for single polymorphisms (GSTM1, GSTT1, NAT2*5A, NAT2*6A, and NAT2*7A), haplotypes, and gene-environment and gene-gene interactions.
resultsWe found an association between ARHI and GSTT1 and GSTM1 in the Finnish population sample, and with NAT2*6A in the general European population sample. The latter finding replicates previously published data.
conclusionAs replication is considered the ultimate proof of true associations in the study of complex disorders, this study provides further support for the involvement of NAT2*6A in ARHI.
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