ArticleBiophysical journal2007
Biased random walk by stochastic fluctuations of chemoattractant-receptor interactions at the lower limit of detection.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Competing chemical gradients change chemotactic dynamics and cell distribution.Physical review. E · 2026Article
- Directed migration of cancer cells: a systems biophysics perspective.Frontiers in cell and developmental biology · 2026Review
- Perspective on Interdisciplinary Approaches on Chemotaxis.Angewandte Chemie (International ed. in English) · 2025Review
- Dictyostelium discoideum chemotaxis is altered by hypoxia to orient streaming toward higher oxygen levels.BMC molecular and cell biology · 2025Article
- Persistent pseudopod splitting is an effective chemotaxis strategy in shallow gradients.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Memoryless chemotaxis with discrete cues.Journal of the Royal Society, Interface · 2024Article
- Trade-offs in concentration sensing in dynamic environments.Biophysical journal · 2024Article
- Spontaneous signal generation by an excitable system for cell migration.Frontiers in cell and developmental biology · 2024Review
- Pseudopod Tracking and Statistics During Cell Movement in Buffer and Chemotaxis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Short-time diffusive fluxes over membrane receptors yields the direction of a signalling source.Royal Society open science · 2023Article
- Cells function as a ternary logic gate to decide migration direction under integrated chemical and fluidic cues.Lab on a chip · 2023Article
- Planar cell polarity: intracellular asymmetry and supracellular gradients of Dachsous.Open biology · 2022Article
- A negative-feedback loop maintains optimal chemokine concentrations for directional cell migration.Nature cell biology · 2020Article
- Evidence of conditioned behavior in amoebae.Nature communications · 2019Article
- Screening by changes in stereotypical behavior during cell motility.Scientific reports · 2019Article
- Physical constraints on accuracy and persistence during breast cancer cell chemotaxis.PLoS computational biology · 2019Article
- Chemotaxis Model for Breast Cancer Cells Based on Signal/Noise Ratio.Biophysical journal · 2018Article
- Chemotaxis and autochemotaxis of self-propelling droplet swimmers.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement.Molecular biology of the cell · 2017Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Binding of ligand to its receptor is a stochastic process that exhibits fluctuations in time and space. In chemotaxis, this leads to a noisy input signal. Therefore, in a gradient of chemoattractant, the cell may occasionally experience a "wrong" gradient of occupied receptors. We obtained a simple equation for P(pos), the probability that half of the cell closest to the source of chemoattractant has higher receptor occupancy than the opposite half of the cell. P(pos) depends on four factors, the gradient property delC/sq. root of C, the receptor characteristic R(t)/K(D), a time-averaging constant I, and nonreceptor noise sigma(B). We measured chemotaxis of Dictyostelium cells to known shallow gradients of cAMP and obtained direct estimates for these constants. Furthermore, we observed that in shallow gradients, the measured chemotaxis index is correlated with P(pos), which suggests that chemotaxis in shallow gradients is a pure biased random walk. From the observed chemotaxis and derived time-averaging constant, we deduce that the gradient transducing second messenger has a lifetime of 2-8 s and a diffusion rate constant of approximately 1 microm(2)/s. Potential candidates for such second messengers are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.