ArticleBiophysical journal2007
A mechanical explanation for cytoskeletal rings and helices in bacteria.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Mechanical property of the helical configuration for a twisted intrinsically straight biopolymer.European biophysics journal : EBJ · 2019Article
- Shape Selection of Surface-Bound Helical Filaments: Biopolymers on Curved Membranes.Biophysical journal · 2016Article
- MreB Orientation Correlates with Cell Diameter in Escherichia coli.Biophysical journal · 2016Article
- An intrinsically disordered linker plays a critical role in bacterial cell division.Seminars in cell & developmental biology · 2015Review
- Getting into shape: How do rod-like bacteria control their geometry?Systems and synthetic biology · 2014Review
- Cell shape can mediate the spatial organization of the bacterial cytoskeleton.Biophysical journal · 2013Article
- The molecular origins of chiral growth in walled cells.Current opinion in microbiology · 2012Review
- Negative-stain electron microscopy of inside-out FtsZ rings reconstituted on artificial membrane tubules show ribbons of protofilaments.Biophysical journal · 2012Article
- FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one.Microbiology and molecular biology reviews : MMBR · 2010Review
- In vivo structure of the E. coli FtsZ-ring revealed by photoactivated localization microscopy (PALM).PloS one · 2010Article
- Simple modeling of FtsZ polymers on flat and curved surfaces: correlation with experimental in vitro observations.PMC biophysics · 2009Article
- Sculpting the bacterial cell.Current biology : CB · 2009Review
- Force generation by a dynamic Z-ring in Escherichia coli cell division.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- FtsZ bacterial cytoskeletal polymers on curved surfaces: the importance of lateral interactions.Biophysical journal · 2008Article
- Reconstitution of contractile FtsZ rings in liposomes.Science (New York, N.Y.) · 2008Article
- In vitro reconstitution of the initial stages of the bacterial cell division machinery.Journal of biological physics · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several bacterial proteins have been shown to polymerize into coils or rings on cell membranes. These include the cytoskeletal proteins MreB, FtsZ, and MinD, which together with other cell components make up what is being called the bacterial cytoskeleton. We believe that these shapes arise, at least in part, from the interaction of the inherent mechanical properties of the protein polymers and the constraints imposed by the curved cell membrane. This hypothesis, presented as a simple mechanical model, was tested with numerical energy-minimization methods from which we found that there are five low-energy polymer morphologies on a rod-shaped membrane: rings, lines, helices, loops, and polar-targeted circles. Analytic theory was used to understand the possible structures and to create phase diagrams that show which parameter combinations lead to which structures. Inverting the results, it is possible to infer the effective mechanical bending parameters of protein polymers from fluorescence images of their shapes. This theory also provides a plausible explanation for the morphological changes exhibited by the Z ring in a sporulating Bacillus subtilis; is used to calculate the mechanical force exerted on a cell membrane by a polymer; and allows predictions of polymer shapes in mutant cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.