ArticleBiophysical journal2007
Effect of the ionic strength and pH on the equilibrium structure of a neurofilament brush.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Dissecting neurofilament tail sequence-phosphorylation-structure relationships with multicomponent reconstituted protein brushes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neurofilament Biophysics: From Structure to Biomechanics.Molecular biology of the cell · 2024Review
- Effects of Ionic Strength on the Morphology, Scattering, and Mechanical Response of Neurofilament-Derived Protein Brushes.Biomacromolecules · 2024Article
- Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach.Biomolecules · 2021Article
- Theoretical Modeling of Chemical Equilibrium in Weak Polyelectrolyte Layers on Curved Nanosystems.Polymers · 2020Review
- A motor neuron strategy to save time and energy in neurodegeneration: adaptive protein stoichiometry.Journal of neurochemistry · 2018Article
- Influence of a GSK3β phosphorylation site within the proximal C-terminus of Neurofilament-H on neurofilament dynamics.Biology open · 2017Article
- Article
- Local regulation of neurofilament transport by myelinating cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Self-consistent field theory for the interactions between keratin intermediate filaments.BMC biophysics · 2013Article
- How the projection domains of NF-L and alpha-internexin determine the conformations of NF-M and NF-H in neurofilaments.European biophysics journal : EBJ · 2010Article
- The polymer brush model of neurofilament projections: effect of protein composition.Biophysical journal · 2010Article
- Structure and interactions of aggrecans: statistical thermodynamic approach.Biophysical journal · 2008Article
- Interplay between liquid crystalline and isotropic gels in self-assembled neurofilament networks.Biophysical journal · 2008Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using the numerical model of Scheutjens and Fleer, we investigated, on a self-consistent field level, the equilibrium structure of the neurofilament brush formed by projection domains of the constituent NF-H, NF-M, and NF-L proteins. The phosphorylation of such a brush is a major regulatory process that triggers the relocation of the H tails from the NF core to the brush periphery. We explore how the pH and the ionic strength affect the rearrangements in the NF brush structure upon phosphorylation. We demonstrate that the translocation of H tails in an individual NF occurs as a sharp cooperative transition below and up to the physiological salt concentration. Regularities of this process are reminiscent of the collapse-to-stretching transition in a cylindrical polyelectrolyte brush in a poor solvent. The effect of pH at physiological ionic strength is noticeable only in the acidic range and is more pronounced for a dephosphorylated NF.
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