ArticleJournal of the American Society for Mass Spectrometry2007
A collision cross-section database of singly-charged peptide ions.
Article in Journal of the American Society for Mass Spectrometry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 86 citations in OpenAlex.
- Assigning Peptide Structure from Ion-Mobility Mass Spectrometry Collision Cross Section Data.Journal of the American Society for Mass Spectrometry · 2025Article
- Spatial Proteomics by Parallel Accumulation-Serial Fragmentation Supported MALDI MS/MS Imaging: A First Glance Into Multiplexed and Spatial Peptide Identification.Rapid communications in mass spectrometry : RCM · 2025Article
- First Generic Teriparatide: Structural and Biological Sameness to Its Reference Medicinal Product.Pharmaceutics · 2024Article
- Deep learning the collisional cross sections of the peptide universe from a million experimental values.Nature communications · 2021Article
- Fundamentals of Ion Mobility-Mass Spectrometry for the Analysis of Biomolecules.Methods in molecular biology (Clifton, N.J.) · 2020Review
- New Frontiers in Lipidomics Analyses using Structurally Selective Ion Mobility-Mass Spectrometry.Trends in analytical chemistry : TRAC · 2019Article
- Evaluating Separation Selectivity and Collision Cross Section Measurement Reproducibility in Helium, Nitrogen, Argon, and Carbon Dioxide Drift Gases for Drift Tube Ion Mobility-Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2019Article
- Ion mobility conformational lipid atlas for high confidence lipidomics.Nature communications · 2019Article
- Ion Mobility Spectrometry-Mass Spectrometry Coupled with Gas-Phase Hydrogen/Deuterium Exchange for Metabolomics Analyses.Journal of the American Society for Mass Spectrometry · 2018Article
- Ion Mobility Collision Cross Section Compendium.Analytical chemistry · 2017Review
- Achieving High Resolution Ion Mobility Separations Using Traveling Waves in Compact Multiturn Structures for Lossless Ion Manipulations.Analytical chemistry · 2016Article
- Characterization of Traveling Wave Ion Mobility Separations in Structures for Lossless Ion Manipulations.Analytical chemistry · 2015Article
- Kinetic intermediates of holo- and apo-myoglobin studied using HDX-TIMS-MS and molecular dynamic simulations.Journal of the American Society for Mass Spectrometry · 2015Article
- Ion mobility-mass spectrometry: time-dispersive instrumentation.Analytical chemistry · 2015Review
- Large-scale collision cross-section profiling on a traveling wave ion mobility mass spectrometer.Journal of the American Society for Mass Spectrometry · 2014Article
- Flavin adenine dinucleotide structural motifs: from solution to gas phase.Analytical chemistry · 2014Article
- Numerical modeling of ion transport in an ESI-MS system.Journal of the American Society for Mass Spectrometry · 2014Article
- Traveling wave ion mobility mass spectrometry and ab initio calculations of phosphoric acid clusters.Journal of the American Society for Mass Spectrometry · 2014Article
- Direct observation of differences of carotenoid polyene chain cis/trans isomers resulting from structural topology.Analytical chemistry · 2014Article
- Conformational ordering of biomolecules in the gas phase: nitrogen collision cross sections measured on a prototype high resolution drift tube ion mobility-mass spectrometer.Analytical chemistry · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A database of ion-neutral collision cross-sections for singly-charged peptide ions is presented. The peptides included in the database were generated by enzymatic digestion of known proteins using three different enzymes, resulting in peptides that differ in terms of amino acid composition as well as N-terminal and C-terminal residues. The ion-neutral collision cross-sections were measured using ion mobility (IM) spectrometry that is directly coupled to a time-of-flight (TOF) mass spectrometer. The ions were formed by a matrix-assisted laser desorption ionization (MALDI) ion source operated at pressures (He bath gas) of 2 to 3 torr. The majority (63%) of the peptide ion collision cross-sections correlate well with structures that are best described as charge-solvated globules, but a significant number of the peptide ions exhibit collision cross-sections that are significantly larger or smaller than the average, globular mobility-mass correlation. Of the peptide ions having larger than average collision cross-sections, approximately 71% are derived from trypsin digestion (C-terminal Arg or Lys residues) and most of the peptide ions that have smaller (than globular) collision cross-sections are derived from pepsin digestion (90%).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.