ArticleJournal of neuroimmunology2007
TNFalpha-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-I.
Article in Journal of neuroimmunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Increased A1 astrocyte activation-driven hippocampal neural network abnormality mediates delirium-like behavior in aged mice undergoing cardiac surgery.Aging cell · 2024Article
- GWAS-identified hyperuricemia-associated IGF1R variant rs6598541 has a limited role in urate mediated inflammation in human mononuclear cells.Scientific reports · 2024Article
- Insulin-Like Growth Factor-1 Enhances Motoneuron Survival and Inhibits Neuroinflammation After Spinal Cord Transection in Zebrafish.Cellular and molecular neurobiology · 2022Article
- Painful Diabetic Neuropathy Is Associated with Compromised Microglial IGF-1 Signaling Which Can Be Rescued by Green Tea Polyphenol EGCG in Mice.Oxidative medicine and cellular longevity · 2022Article
- Dysregulation of IGF-1/GLP-1 signaling in the progression of ALS: potential target activators and influences on neurological dysfunctions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- ADAM Metalloproteinase Domain 17 Regulates Cholestasis-Associated Liver Injury and Sickness Behavior Development in Mice.Frontiers in immunology · 2021Article
- Glial neuroimmune signaling in opioid reward.Brain research bulletin · 2020Review
- Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner.Nature communications · 2017Article
- Insulin-Like Growth Factor-1 and Neuroinflammation.Frontiers in aging neuroscience · 2017Review
- The development of depression-like behavior is consolidated by IL-6-induced activation of locus coeruleus neurons and IL-1β-induced elevated leptin levels in mice.Psychopharmacology · 2016Article
- Review
- Chronic HCV infection and inflammation: Clinical impact on hepatic and extra-hepatic manifestations.World journal of hepatology · 2013Review
- Differential roles of TNFR1 and TNFR2 signaling in adult hippocampal neurogenesis.Brain, behavior, and immunity · 2013Article
- Immune-neural connections: how the immune system's response to infectious agents influences behavior.The Journal of experimental biology · 2013Review
- Inflammation in neurological and psychiatric diseases.Inflammopharmacology · 2012Review
- Humoral sleep regulation; interleukin-1 and tumor necrosis factor.Vitamins and hormones · 2012Review
- Neuropsychological alterations in hepatitis C infection: the role of inflammation.World journal of gastroenterology · 2011Article
- Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice.Journal of neuroinflammation · 2011Article
- Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior.Psychopharmacology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
A variety of pathogenic insults cause synthesis of tumor necrosis factor (TNF)alpha in the brain, resulting in sickness behavior. Here we used TNF-receptor (TNF-R)2-deficient and wild-type mice to demonstrate that the reduction in social exploration of a novel juvenile, the increase in immobility and the loss of body weight caused by central TNFalpha (i.c.v., 50 ng/mouse) are blocked by central pre-treatment with the multifunctional peptide, insulin-like growth factor (IGF-I; i.c.v., 300 ng/mouse). These results establish that sickness behavior induced by central TNFalpha via the TNF-R1 (p55) is directly opposed by IGF-I in the brain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.