ArticleJournal of neuroscience methods2007
Electrophysiological and pharmacological validation of vagal afferent fiber type of neurons enzymatically isolated from rat nodose ganglia.
Article in Journal of neuroscience methods, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- TTX-S/TTX-R NaActa physiologica (Oxford, England) · 2026Article
- Sub-threshold depolarization differentially regulated by multiple ion channels plays a key role in initiation of baroreflex afferent neurotransmission evidenced from baroreceptor terminals to its cell bodies.Frontiers of medicine · 2025Article
- Article
- Kv2 channels contribute to neuronal activity within the vagal afferent-nTS reflex arc.American journal of physiology. Cell physiology · 2024Article
- Piezo1 channel activation facilitates baroreflex afferent neurotransmission with subsequent blood pressure reduction in control and hypertension rats.Acta pharmacologica Sinica · 2024Article
- Diabetes mellitus differently affects electrical membrane properties of vagal afferent neurons of rats.Physiological reports · 2023Article
- Estrogen-dependent depressor response of melatonin via baroreflex afferent function and intensification of PKC-mediated NaActa pharmacologica Sinica · 2022Article
- Bradykinin-mediated estrogen-dependent depressor response by direct activation of female-specific distribution of myelinated Ah-type baroreceptor neurons in rats.CNS neuroscience & therapeutics · 2022Article
- Different sensitivity of action potential generation to the rate of depolarization in vagal afferent A-fiber versus C-fiber neurons.Journal of neurophysiology · 2021Article
- Excitation properties of computational models of unmyelinated peripheral axons.Journal of neurophysiology · 2021Article
- Sensory Axon Growth Requires Spatiotemporal Integration of CaSR and TrkB Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Spontaneous activities in baroreflex afferent pathway contribute dominant role in parasympathetic neurocontrol of blood pressure regulation.CNS neuroscience & therapeutics · 2018Article
- Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms.Molecular metabolism · 2018Article
- Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons.PloS one · 2018Article
- Nitric oxide donor protects against acetic acid-induced gastric ulcer in rats via S-nitrosylation of TRPV1 on vagus nerve.Scientific reports · 2017Article
- Modeling the differentiation of A- and C-type baroreceptor firing patterns.Journal of computational neuroscience · 2017Article
- Neuropeptide Y-mediated sex- and afferent-specific neurotransmissions contribute to sexual dimorphism of baroreflex afferent function.Oncotarget · 2016Article
- Sodium channel diversity in the vestibular ganglion: NaV1.5, NaV1.8, and tetrodotoxin-sensitive currents.Journal of neurophysiology · 2016Article
- Localization of TRPV1 and P2X3 in unmyelinated and myelinated vagal afferents in the rat.Journal of chemical neuroanatomy · 2016Article
- Article
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2 authors.
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Abstract
An unavoidable consequence of enzymatic dispersion of sensory neurons from intact ganglia is loss of the axon and thus the ability to classify afferent fiber type based upon conduction velocity (CV). An intact rat nodose ganglion preparation was used to randomly sample neurons (n=76) using the patch clamp technique. Reliable electrophysiological and chemophysiological correlates of afferent fiber type were established for use with isolated neuron preparations. Myelinated afferents (approximately 25%) formed two groups exhibiting strikingly different functional profiles. One group (n=10) exhibited CVs in excess of 10 m/s and narrow (<1 ms) action potentials (APs) while the other (n=9) had CVs as low as 4m/s and broad (>2 ms) APs that closely approximated those identified as unmyelinated afferents (n=57) with CVs less than 1m/s. A cluster analysis of select measures from the AP waveforms strongly correlated with CV, producing three statistically unique populations (p<0.05). These groupings aligned with our earlier hypothesis (Jin et al., 2004) that a differential sensitivity to the selective purinergic and vanilloid receptor agonists can be used as reliable pharmacological indicators of vagal afferent fiber type. These metrics were further validated using an even larger population of isolated (n=240) nodose neurons. Collectively, these indicators of afferent fiber type can be used to provide valuable insight concerning the relavence of isolated cellular observations to integrated afferent function of visceral organ systems.
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