ArticleBMC developmental biology2007
The role of survivin in angiogenesis during zebrafish embryonic development.
Article in BMC developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Isopimpinellin extends antiangiogenic effect through overexpression of miR-15b-5p and downregulating angiogenic stimulators.Molecular biology reports · 2022Article
- Article
- Clinical Utility of Survivin (BIRC5), Novel Cardiac Biomarker, as a Prognostic Tool Compared to High-sensitivity C-reactive Protein, Heart-type Fatty Acid Binding Protein and Revised Lee Score in Elderly Patients Scheduled for Major Non-cardiac Surgery: A Prospective Pilot Study.Journal of medical biochemistry · 2018Article
- Glomerulocapillary miRNA response to HLA-class I antibody in vitro and in vivo.Scientific reports · 2017Article
- Magnetic nanoparticles: a strategy to target the choroidal layer in the posterior segment of the eye.Scientific reports · 2017Article
- Vegfa signaling promotes zebrafish intestinal vasculature development through endothelial cell migration from the posterior cardinal vein.Developmental biology · 2016Article
- The twisted survivin connection to angiogenesis.Molecular cancer · 2015Review
- The chromosomal passenger protein birc5b organizes microfilaments and germ plasm in the zebrafish embryo.PLoS genetics · 2013Article
- The apoptosis inhibitor survivin prevents insect midgut from cell death during postembryonic development.Molecular biology reports · 2012Article
- How blood vessel networks are made and measured.Cells, tissues, organs · 2012Review
- Integration of CNS survival and differentiation by HIF2α.Cell death and differentiation · 2011Article
- Visceral regeneration in a sea cucumber involves extensive expression of survivin and mortalin homologs in the mesothelium.BMC developmental biology · 2010Article
- Survivin as an immunotherapeutic target for adult and pediatric malignant brain tumors.Cancer immunology, immunotherapy : CII · 2010Review
- Hyperglycemia attenuates angiogenic capability of survivin in endothelial cells.Microvascular research · 2009Article
- Significance of survivin, caspase-3, and VEGF expression in thyroid carcinoma.Clinical and experimental medicine · 2009Article
- Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.Matrix biology : journal of the International Society for Matrix Biology · 2009Article
- Article
- Role of the 2 zebrafish survivin genes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis.BMC developmental biology · 2009Article
- Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.Developmental cell · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurvivin is the smallest member of the inhibitor of apoptosis (IAP) gene family. Recently, the zebrafish survivin-1 gene has been cloned, showing remarkable sequence identity and similarity over the BIR domain compared with human and mouse survivin gene. Here we investigated the role of survivin in angiogenesis during zebrafish development. Morpholinos (MOs) targeting the 5' untranslated region (UTR) (SurUTR) and sequences flanking the initiation codon (SurATG) of zebrafish survivin-1 gene were injected into embryos at 1-4 cell stage. Vasculature was examined by microangiography and GFP expression in Tg(fli1:EGFP)y1 embryos.
resultsIn embryos co-injected with SurUTR and SurATG-MOs, vasculogenesis was intact but angiogenesis was markedly perturbed, especially in the inter-segmental vessels (ISV) and dorsal longitudinal anastomotic vessels (DLAV) of the trunk, the inner optic circle and optic veins of developing eyes and the sub-intestinal vessels. Apoptosis was increased, as shown by TUNEL staining and increase in caspase-3 activity. Efficacy of SurUTR and SurATG-MOs was demonstrated by translation inhibition of co-injected 5'UTR survivin:GFP plasmids. The phenotypes could be recapitulated by splice-site MO targeting the exon2-intron junction of survivin gene and rescued by survivin mRNA. Injection of human vascular endothelial growth factor (VEGF) protein induced ectopic angiogenesis and increased survivin expression, whereas treatment with a VEGF receptor inhibitor markedly reduced angiogenesis and suppressed survivin expression.
conclusionSurvivin is involved in angiogenesis during zebrafish development and may be under VEGF regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.