ArticleClinical and experimental immunology2007
Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France.
Article in Clinical and experimental immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Association between maternal HIV infection and low birth weight and prematurity: a meta-analysis of cohort studies.BMC pregnancy and childbirth · 2015Pooled it
- Measles Immunity at 4.5 Years of Age Following Vaccination at 9 and 15-18 Months of Age Among Human Immunodeficiency Virus (HIV)-infected, HIV-exposed-uninfected, and HIV-unexposed Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Trial
- Effect of HIV exposure and timing of antiretroviral therapy initiation on immune memory responses to diphtheria, tetanus, whole cell pertussis and hepatitis B vaccines.Expert review of vaccines · 2019Trial
- Insights Into Circulating Cytokine Dynamics During Pregnancy in HIV-Infected Beninese Exposed to Plasmodium falciparum Malaria.The American journal of tropical medicine and hygiene · 2015Trial
- Effect of multivitamin supplementation on measles vaccine response among HIV-exposed uninfected Tanzanian infants.Clinical and vaccine immunology : CVI · 2013Trial
- Autism outcomes and neurobehavioural markers in young children born to mothers with HIV in Kenya: a protocol for the Alama project.BMJ open · 2026Article
- Characterizing immune activation in HIV-exposed but uninfected infants in the first year of life.Frontiers in immunology · 2026Observational
- Distinct cytokine profiles in late pregnancy in Ugandan people with HIV.Scientific reports · 2024Article
- Article
- Association of maternal and infant inflammation with neurodevelopment in HIV-exposed uninfected children in a South African birth cohort.Brain, behavior, and immunity · 2021Article
- Higher Transplacental Pathogen-Specific Antibody Transfer Among Pregnant Women Randomized to Triple Antiretroviral Treatment Versus Short Course Zidovudine.The Pediatric infectious disease journal · 2018Article
- Altered Toll-Like Receptor-4 Response to Lipopolysaccharides in Infants Exposed to HIV-1 and Its Preventive Therapy.Frontiers in immunology · 2018Article
- Immunogenicity of Hepatitis B Vaccine in HIV Exposed Uninfected Infants.Indian journal of pediatrics · 2016Article
- Transfer of Maternal Antimicrobial Immunity to HIV-Exposed Uninfected Newborns.Frontiers in immunology · 2016Review
- Impact of maternal HIV-1 viremia on lymphocyte subsets among HIV-exposed uninfected infants: protective mechanism or immunodeficiency.BMC infectious diseases · 2014Article
- Low birth weight in perinatally HIV-exposed uninfected infants: observations in urban settings in Cameroon.PloS one · 2014Article
- Severity of maternal HIV-1 disease is associated with adverse birth outcomes in Malawian women: a cohort study.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life.Clinical and vaccine immunology : CVI · 2013Article
- Do children exposed to human immunodeficiency virus but not infected actually have a more robust response to hepatitis B vaccination than their nonexposed peers?Clinical and vaccine immunology : CVI · 2012Article
- Impaired humoral response to vaccines among HIV-exposed uninfected infants.Clinical and vaccine immunology : CVI · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokines are involved in regulating HIV-1 infection. They are also placental environment major components. We assessed the potential impact of HIV-1 infection and/or anti-retroviral drugs on the placental cytokine profiles that may be involved in controlling HIV-1 placental dissemination. Placental explants were obtained after elective caesarean section from anti-retroviral-treated HIV-1-infected pregnant women and from HIV-1 non-infected pregnant women. The main placental cytokines were assessed for protein secretion in the supernatants of 24-h placental culture explants and/or in uncultured placental explants for mRNA expression levels. The cytokine profiles were different between the HIV-1-infected and the non-infected groups. Higher medians of leukaemia inhibiting factor (LIF), tumour necrosis factor (TNF)-alpha and interleukin (IL)-8 secretion were found in the 24-h culture supernatant of term placenta from HIV-1-infected women. High median levels of IL-16 and regulated upon activation normal T cell expressed and secreted (RANTES) levels were found in both groups. The mRNA expression medians were lower for TNF-alpha and IL-8 and higher for stromal cell-derived factor-1 (SDF-1) in uncultured placental explants from HIV-1-infected women. In the HIV-1-infected group, but not in the non-infected group, the secretion levels of TNF-alpha and IL-8, as well as their mRNA expression levels, were highly positively correlated; furthermore, their secretion levels were correlated positively with LIF and IL-10 secretion levels. We found no correlation between the cytokine levels and the immunovirological status of the HIV-1-infected mothers or the type or duration of treatment. These results highlight the potential impact of HIV-1 and of the anti-retroviral treatments on the placental cytokines pattern, independently of their anti-viral activity.
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Registered trials
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