ArticleWorld journal of gastroenterology2007
Duodenal intraepithelial T lymphocytes in patients with functional dyspepsia.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Guideline
- The Duodenal Microenvironment in Functional Dyspepsia.Journal of neurogastroenterology and motility · 2025Review
- Review
- Research trends in the field of the gut-brain interaction: Functional dyspepsia in the spotlight - An integrated bibliometric and science mapping approach.Frontiers in neuroscience · 2023Review
- Eosinophil and Mast Cell Counts in the Stomach and Duodenum of Patients with Functional Dyspepsia without aThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Article
- Immune Activation in Functional Dyspepsia: Bystander Becoming the Suspect.Frontiers in neuroscience · 2022Review
- Gut microbiota dysbiosis in functional gastrointestinal disorders: Underpinning the symptoms and pathophysiology.JGH open : an open access journal of gastroenterology and hepatology · 2021Review
- A histomorphometric classification system for normal and inflamed mouse duodenum-Quali-quantitative approach.International journal of experimental pathology · 2018Article
- Role of the Duodenum in the Pathogenesis of Functional Dyspepsia: A Paradigm Shift.Journal of neurogastroenterology and motility · 2018Review
- Histomorphological Spectrum of Duodenal Pathology in Functional Dyspepsia Patients.Journal of clinical and diagnostic research : JCDR · 2017Article
- The significance of infectious disease and microbiota in functional gastrointestinal disorders.Journal of general and family medicine · 2017Review
- Evaluation ofExperimental and therapeutic medicine · 2013Article
- Overlap of functional dyspepsia and GERD--diagnostic and treatment implications.Nature reviews. Gastroenterology & hepatology · 2013Review
- What is the difference between Helicobacter pylori-associated dyspepsia and functional dyspepsia?Journal of neurogastroenterology and motility · 2011Article
- Duodenal implications in the pathophysiology of functional dyspepsia.Journal of neurogastroenterology and motility · 2010Article
- Gastrointestinal eosinophils in health, disease and functional disorders.Nature reviews. Gastroenterology & hepatology · 2010Review
- Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia.Alimentary pharmacology & therapeutics · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo quantify the intraepithelial lymphocytes (IELs) and to document the membrane expression of CD4, CD8, TCRgamma delta and adhesion and/or activation-associated molecules (CD103, CD28, CD44, CD69, HLA-DR, CD95/Fas) in the duodenal mucosa of patients with functional dyspepsia (FD) in order to provide arguments for an immunological process in FD.
methodsTwenty-six FD patients according to Rome II criteria (20 were H pylori negative) were studied and compared to 12 healthy adults. IELs were isolated from five duodenal biopsy samples, then quantified by microscopy and flow cytometry while the membrane phenotypes were determined by cytofluorometry.
resultsDuodenal histological examination was normal. In H pylori negative patients, the number of IELs was not different from that in healthy controls. Median percentage expression of CD4, CD8, or TCRgamma delta and CD103, CD44, CD28, CD69 on CD3+ IELs, among the adhesion/activation associated molecules tested, was not different from that in healthy controls. In contrast, the median percentage expression of CD95/Fas [22 (9-65) vs 45 (19-88), P=0.03] and HLA-DR expressing CD3+ IELs [4 (0-30) vs 13 (4-42), P=0.04] was significantly lower in the H pylori negative FD group than in healthy controls, respectively. The number of IELs was significantly greater in H pylori positive FD patients than in healthy controls [median ratio for 100 enterocytes 27.5 (6.7-62.5) vs 10.8 (3-33.3), P=0.02] due to a higher number of CD8+ CD3+ IELs.
conclusionIn H pylori negative FD patients, the phenotypic characterization of IELs suggests that we cannot exclude a role of IELs in FD.
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