ArticleWorld journal of gastroenterology2007
Expression of SNC73, a transcript of the immunoglobulin alpha-1 gene, in human epithelial carcinomas.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Expression and Function of Mammary Epithelial Cell-Derived Immunoglobulins.Advances in experimental medicine and biology · 2024Review
- Non B Cell-Derived Immunoglobulins in Intestinal Tract.Advances in experimental medicine and biology · 2024Review
- Functions and Clinical Relevance of Liver-Derived Immunoglobulins.Advances in experimental medicine and biology · 2024Review
- The Expression of Non B Cell-Derived Immunoglobulins.Advances in experimental medicine and biology · 2024Review
- Current insights into the expression and functions of tumor-derived immunoglobulins.Cell death discovery · 2021Review
- Immunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis.Frontiers in immunology · 2021Review
- Cancer-derived sialylated IgG promotes tumor immune escape by binding to Siglecs on effector T cells.Cellular & molecular immunology · 2020Article
- Article
- Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.Heliyon · 2016Article
- Aberrant high expression of immunoglobulin G in epithelial stem/progenitor-like cells contributes to tumor initiation and metastasis.Oncotarget · 2015Article
- IgG and IgA with potential microbial-binding activity are expressed by normal human skin epidermal cells.International journal of molecular sciences · 2015Article
- TGFβ receptor 1: an immune susceptibility gene in HPV-associated cancer.Cancer research · 2014Article
- Activation of the Ig Iα1 promoter by the transcription factor Ets-1 triggers Ig Iα1-Cα1 germline transcription in epithelial cancer cells.Cellular & molecular immunology · 2014Article
- Article
- Proteomic analysis of formalin-fixed paraffin-embedded pancreatic tissue using liquid chromatography tandem mass spectrometry.Pancreas · 2012Article
- Article
- Difference gel electrophoresis identifies differentially expressed proteins in endoscopically collected pancreatic fluid.Electrophoresis · 2011Article
- Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells.PloS one · 2011Article
- Inhibition of in vitro tumor cell growth by RP215 monoclonal antibody and antibodies raised against its anti-idiotype antibodies.Cancer immunology, immunotherapy : CII · 2010Article
- Immunoglobulin expression in non-lymphoid lineage and neoplastic cells.The American journal of pathology · 2009Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the expression of SNC73, a trans-cript of the immunoglobulin alpha-1 gene (IgA1-H chain), in human epithelia-derived tumor cells.
methodsTotal RNAs and cell lysates were prepared from five different human epithelial cell lines derived from lung, stomach, liver, skin, and breast, respectively. RT-PCR and immunoblot analysis of these five cell lines were done. Both RT-PCR and immunochemistry were used to detect the expression of SNC73 in these cell lines. We also examined the expression of SNC73 in normal epithelial cells of colon mucosa by in situ hybridization. RT-PCR and immunoblot analysis were used to determine whether the recombination activating gene1/2 (RAG1 and RAG2) is present. The expression of three immunoglobulin transcription factors, EBF, E2A and Pax5, and the heavy chain of IgA1 and two types of light chains of immunoglobulin (kappa and lambda) in the aforementioned cell lines were analyzed by RT-PCR and immunochemistry, respectively. All the RT-PCR products were analyzed by sequencing.
resultsThe results of RT-PCR and immunochemistry showed that both mRNA and protein of SNC73 were expressed in five human epithelia-derived cancer cell lines. These data were further confirmed in the normal epithelial cells of colon mucosa by in situ hybridization. Also, the heavy chain of IgA1 and kappa light chain were detected in these cells, but no lambda light chain was obse-rved. Both RAG1 and RAG2 were expressed in these human epithelia-derived cancer cell lines and the sequence was identical to that expressed in pre-B and pre-T cells. In addition to RAG1 and RAG2, the mRNA in one of the immunoglobulin transcription factors, EBF, was also detected in these cell lines, and Pax5 was only expressed in SW480 cells, but no expression of E2A was observed in all the five cell lines.
conclusionImmunoglobulin A1 is originally expressed and V(D)J recombination machine is also present in non-lymphoid cells, suggesting that V(D)J recombination machine mediates the assembly of immunoglobulin A1 in non-lymphoid cells as in pre-lymphocytes.
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