ArticleThe Journal of membrane biology2007
Mechanism of lysophosphatidylcholine-induced lysosome destabilization.
Article in The Journal of membrane biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Multi-Omics Reveals Dysregulation of the Endosome-Lysosome-Autophagy Axis and Immune-Inflammatory Imbalance in Elderly Sepsis.Clinical interventions in aging · 2026Article
- Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid metabolism.Scientific reports · 2025Article
- Cationic amphiphilic drugs induce accumulation of cytolytic lysoglycerophospholipids in the lysosomes of cancer cells and block their recycling into common membrane glycerophospholipids.Molecular biology of the cell · 2024Article
- Ursolic Acid Impairs Cellular Lipid Homeostasis and Lysosomal Membrane Integrity in Breast Carcinoma Cells.Cells · 2022Article
- Lysosomal Changes in Mitosis.Cells · 2022Article
- Phospholipases and Reactive Oxygen Species Derived Lipid Biomarkers in Healthy and Diseased Humans and Animals - A Focus on Lysophosphatidylcholine.Frontiers in physiology · 2021Review
- Evaluation of Serum Lysophosphatidic Acid and Lysophosphatidylcholine Levels in Major Depressive Disorder Patients.Cureus · 2020Article
- The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases.Biochimica et biophysica acta. Proteins and proteomics · 2020Review
- Cationic amphiphilic drugs induce elevation in lysoglycerophospholipid levels and cell death in leukemia cells.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Protein kinase C-δ isoform mediates lysosome labilization in DNA damage-induced apoptosis.International journal of oncology · 2011Article
- Regulation of apoptosis-associated lysosomal membrane permeabilization.Apoptosis : an international journal on programmed cell death · 2010Review
- Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells.Journal of proteomics · 2009Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lysosomal destabilization is critical for the organelle and living cells. Phospholipase A(2 )(PLA(2)) was shown to be able to destabilize lysosomes under some conditions. By what mechanism the enzyme affects lysosomal stability is not fully studied. In this study, we investigated the effects of lysophosphatidylcholine (lysoPC), a PLA(2)-produced lipid metabolite, on lysosomal ion permeability, osmotic sensitivity and stability. By measuring lysosomal beta-hexosaminidase free activity, membrane potential, proton leakage and their enzyme latency loss in hypotonic sucrose medium, we established that lysoPC could increase the lysosomal permeability to both potassium ions and protons and enhance lysosomal osmotic sensitivity. These changes in lysosomal membrane properties promoted entry of potassium ions into lysosomes via K(+)/H(+) exchange. The resultant osmotic imbalance across the membranes led to losses of lysosomal integrity. The enhancement of lysosomal osmotic sensitivity caused the lysosomes to become more liable to destabilization in osmotic shock. These results suggest that lysoPC may play a key role in PLA(2)-induced lysosomal destabilization.
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