ArticlePharmaceutical research2007
Residence time dispersion as a general measure of drug distribution kinetics: estimation and physiological interpretation.
Article in Pharmaceutical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comparison of distributed and compartmental models of drug disposition: assessment of tissue uptake kinetics.Journal of pharmacokinetics and pharmacodynamics · 2016Article
- Exponential tails of drug disposition curves: reality or appearance?Journal of pharmacokinetics and pharmacodynamics · 2014Article
- Circulatory model of vascular and interstitial distribution kinetics of rocuronium: a population analysis in patients.Journal of pharmacokinetics and pharmacodynamics · 2011Article
- How does obesity affect residence time dispersion and the shape of drug disposition curves? Thiopental as an example.Journal of pharmacokinetics and pharmacodynamics · 2008Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
purposeTo evaluate distribution kinetics of drugs by the relative dispersion of disposition residence time and demonstrate its uses, interpretation and limitations. MATERIALS AND
methodsThe relative dispersion was estimated from drug disposition data of inulin and digoxin fitted by three-exponential functions, and calculated from compartmental parameters published for fentanyl and alfentanil. An interpretation is given in terms of a lumped organs model and the distributional equilibration process in a noneliminating system.
resultsAs a measure of the deviation from mono-exponential disposition (one-compartment behavior), the relative dispersion provides information on the distribution kinetics of drugs, i.e., diffusion-limited distribution or slow tissue binding, without assuming a specific structural model. It also defines the total distribution clearance which has a clear physical meaning.
conclusionThe residence time dispersion is a model-independent measure that can be used to characterize the distribution kinetics of drugs and to reveal the influence of disease states. It can be estimated with high precision from drug disposition data.
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Registered trials
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