ArticleBritish journal of sports medicine2007
Salbutamol exhibits androgenic activity in vitro.
Article in British journal of sports medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Effects of β2-adrenergic stimulation on exercise capacity in normal subjects.European journal of applied physiology · 2011Trial
- The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation.Breast cancer research : BCR · 2012Article
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Authors and funding
4 authors.
Funding
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Abstract
backgroundSalbutamol has been shown to mediate anabolic effects after intravenous administration. However, the mechanism responsible for the anabolic actions of salbutamol remains unknown.
aimTo investigate the potential mechanism by which salbutamol mediates anabolic effects in vitro.
methodsThe potential androgenic activity of salbutamol was investigated in vitro by the A-Screen assay that measures androgen-dependent inhibition of proliferation of the androgen receptor (AR)-positive human mammary carcinoma cell line, MCF7-AR1.
resultsThe assay was validated with three known androgens; methyltrienolone (R1881), 5alpha-dihydrotestosterone (DHT) and danazol. IC50 values of R1881, DHT and danazol, 4.41x10(-11), 4.44x10(-11) and 1.08x10(-8) M, respectively, were in the ranges known from earlier studies. Our results demonstrate that salbutamol exhibits androgenic activity, with an IC50 value of 8.93x10(-6) M. Anti-estrogenic or cytotoxic effects, which might have interfered with the assay, were excluded by additional experiments on wild-type MCF7 and MCF7-AR1 cells, respectively.
conclusionThese data indicate that salbutamol exerts anabolic effects through androgen receptor agonistic activity in vitro.
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