ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2007
Stochastic simulations of minimal self-reproducing cellular systems.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Protocell Dynamics: Modelling Growth and Division of Lipid Vesicles Driven by an Autocatalytic Reaction.Life (Basel, Switzerland) · 2025Article
- Protocells Either Synchronize or Starve.Entropy (Basel, Switzerland) · 2025Article
- Models of Protocells Undergoing Asymmetrical Division.Entropy (Basel, Switzerland) · 2024Article
- Small-molecule autocatalysis drives compartment growth, competition and reproduction.Nature chemistry · 2024Article
- Multistable Protocells Can Aid the Evolution of Prebiotic Autocatalytic Sets.Life (Basel, Switzerland) · 2023Article
- When Is a Reaction Network a Metabolism? Criteria for Simple Metabolisms That Support Growth and Division of Protocells.Life (Basel, Switzerland) · 2021Article
- Sustainable Growth and Synchronization in Protocell Models.Life (Basel, Switzerland) · 2019Article
- Molecular Evolution in a Peptide-Vesicle System.Life (Basel, Switzerland) · 2018Article
- Permeability-driven selection in a semi-empirical protocell model: the roots of prebiotic systems evolution.Scientific reports · 2017Article
- Emergent chemical behavior in variable-volume protocells.Life (Basel, Switzerland) · 2015Article
- Modelling lipid competition dynamics in heterogeneous protocell populations.Scientific reports · 2014Article
- Stochastic simulations of minimal cells: the Ribocell model.BMC bioinformatics · 2012Article
- Two different template replicators coexisting in the same protocell: stochastic simulation of an extended chemoton model.PloS one · 2011Article
- From self-assembled vesicles to protocells.Cold Spring Harbor perspectives in biology · 2010Review
- Generic Darwinian selection in catalytic protocell assemblies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2007Article
- Synthetic protocell biology: from reproduction to computation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2007Review
- Question 7: new aspects of interactions among vesicles.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper is a theoretical attempt to gain insight into the problem of how self-assembling vesicles (closed bilayer structures) could progressively turn into minimal self-producing and self-reproducing cells, i.e. into interesting candidates for (proto)biological systems. With this aim, we make use of a recently developed object-oriented platform to carry out stochastic simulations of chemical reaction networks that take place in dynamic cellular compartments. We apply this new tool to study the behaviour of different minimal cell models, making realistic assumptions about the physico-chemical processes and conditions involved (e.g. thermodynamic equilibrium/non-equilibrium, variable volume-to-surface relationship, osmotic pressure, solute diffusion across the membrane due to concentration gradients, buffering effect). The new programming platform has been designed to analyse not only how a single protometabolic cell could maintain itself, grow or divide, but also how a collection of these cells could 'evolve' as a result of their mutual interactions in a common environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.