ArticleJournal of controlled release : official journal of the Controlled Release Society2007
Biodegradable elastomeric scaffolds with basic fibroblast growth factor release.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 158 citations in OpenAlex.
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- Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread.Journal of functional biomaterials · 2019Article
- Bioprinting of Vascularized Tissue Scaffolds: Influence of Biopolymer, Cells, Growth Factors, and Gene Delivery.Journal of healthcare engineering · 2019Review
- Nitro-Oleic Acid (NOTissue engineering. Part A · 2018Article
- Development of controlled drug delivery systems for bone fracture-targeted therapeutic delivery: A review.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2018Review
- Biomaterial Scaffolds in Regenerative Therapy of the Central Nervous System.BioMed research international · 2018Review
- The In Vitro Enzymatic Degradation of Cross-Linked Poly(trimethylene carbonate) Networks.Polymers · 2017Article
- The in Vitro and in Vivo Degradation of Cross-Linked Poly(trimethylene carbonate)-Based Networks.Polymers · 2016Article
- High Modulus Biodegradable Polyurethanes for Vascular Stents: Evaluation of Accelerated in vitro Degradation and Cell Viability of Degradation Products.Frontiers in bioengineering and biotechnology · 2015Article
- Tunable drug-loading capability of chitosan hydrogels with varied network architectures.Acta biomaterialia · 2014Article
- Tunable delivery of siRNA from a biodegradable scaffold to promote angiogenesis in vivo.Advanced materials (Deerfield Beach, Fla.) · 2014Article
- Gelatin-modified polyurethanes for soft tissue scaffold.TheScientificWorldJournal · 2013Article
- Biodegradable photo-crosslinked alginate nanofibre scaffolds with tuneable physical properties, cell adhesivity and growth factor release.European cells & materials · 2012Article
- Biomolecule gradient in micropatterned nanofibrous scaffold for spatiotemporal release.Langmuir : the ACS journal of surfaces and colloids · 2012Article
- Osteoblast growth and bone-healing response to three-dimensional poly(ε-caprolactone fumarate) scaffolds.Journal of tissue engineering and regenerative medicine · 2012Article
- Sustained local delivery of siRNA from an injectable scaffold.Biomaterials · 2012Article
- Controlled release of IGF-1 and HGF from a biodegradable polyurethane scaffold.Pharmaceutical research · 2011Article
- A G-CSF functionalized scaffold for stem cells seeding: a differentiating device for cardiac purposes.Journal of cellular and molecular medicine · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Scaffolds that better approximate the mechanical properties of cardiovascular and other soft tissues might provide a more appropriate mechanical environment for tissue development or healing in vivo. An ability to induce local angiogenesis by controlled release of an angiogenic factor, such as basic fibroblast growth factor (bFGF), from a biodegradable scaffold with mechanical properties more closely approximating soft tissue could find application in a variety of settings. Toward this end biodegradable poly(ester urethane)urea (PEUU) scaffolds loaded with bFGF were fabricated by thermally induced phase separation. Scaffold morphology, mechanical properties, release kinetics, hydrolytic degradation and bioactivity of the released bFGF were assessed. The scaffolds had inter-connected pores with porosities of 90% or greater and pore sizes ranging from 34-173 microm. Scaffolds had tensile strengths of 0.25-2.8 MPa and elongations at break of 81-443%. Incorporation of heparin into the scaffold increased the initial burst release of bFGF, while the initial bFGF loading content did not change release kinetics significantly. The released bFGF remained bioactive over 21 days as assessed by smooth muscle mitogenicity. Scaffolds loaded with bFGF showed slightly higher degradation rates than unloaded control scaffolds. Smooth muscle cells seeded into the scaffolds with bFGF showed higher cell densities than for control scaffolds after 7 days of culture. The bFGF-releasing PEUU scaffolds thus exhibited a combination of mechanical properties and bioactivity that might be attractive for use in cardiovascular and other soft tissue applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.