ArticleGenetics2007
A maternal screen for genes regulating Drosophila oocyte polarity uncovers new steps in meiotic progression.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Coordinating Proliferation, Polarity, and Cell Fate in theFrontiers in cell and developmental biology · 2020Review
- Assembly and Function of Gonad-Specific Non-Membranous Organelles inNon-coding RNA · 2019Review
- Mapping Second Chromosome Mutations to Defined Genomic Regions inG3 (Bethesda, Md.) · 2018Article
- The meiotic checkpoint network: step-by-step through meiotic prophase.Cold Spring Harbor perspectives in biology · 2014Review
- Next generation organelles: structure and role of germ granules in the germline.Molecular reproduction and development · 2013Review
- A mosaic genetic screen for genes involved in the early steps of Drosophila oogenesis.G3 (Bethesda, Md.) · 2013Article
- The conserved kinase SRPK regulates karyosome formation and spindle microtubule assembly in Drosophila oocytes.Journal of cell science · 2012Article
- Meiosis in male Drosophila.Spermatogenesis · 2012Article
- The Drosophila actin regulator ENABLED regulates cell shape and orientation during gonad morphogenesis.PloS one · 2012Article
- The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity.PloS one · 2011Article
- Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis.RNA (New York, N.Y.) · 2010Article
- Building RNA-protein granules: insight from the germline.Trends in cell biology · 2010Review
- Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- Hedgehog does not guide migrating Drosophila germ cells.Developmental biology · 2009Article
- Differential requirements of a mitotic acetyltransferase in somatic and germ line cells.Developmental biology · 2008Article
- Tre1 GPCR initiates germ cell transepithelial migration by regulating Drosophila melanogaster E-cadherin.The Journal of cell biology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meiotic checkpoints monitor chromosome status to ensure correct homologous recombination, genomic integrity, and chromosome segregation. In Drosophila, the persistent presence of double-strand DNA breaks (DSB) activates the ATR/Mei-41 checkpoint, delays progression through meiosis, and causes defects in DNA condensation of the oocyte nucleus, the karyosome. Checkpoint activation has also been linked to decreased levels of the TGFalpha-like molecule Gurken, which controls normal eggshell patterning. We used this easy-to-score eggshell phenotype in a germ-line mosaic screen in Drosophila to identify new genes affecting meiotic progression, DNA condensation, and Gurken signaling. One hundred eighteen new ventralizing mutants on the second chromosome fell into 17 complementation groups. Here we describe the analysis of 8 complementation groups, including Kinesin heavy chain, the SR protein kinase cuaba, the cohesin-related gene dPds5/cohiba, and the Tudor-domain gene montecristo. Our findings challenge the hypothesis that checkpoint activation upon persistent DSBs is exclusively mediated by ATR/Mei-41 kinase and instead reveal a more complex network of interactions that link DSB formation, checkpoint activation, meiotic delay, DNA condensation, and Gurken protein synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.