ArticleGenetics2007
Bayesian mapping of genomewide interacting quantitative trait loci for ordinal traits.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A semi-parametric Bayesian model for semi-continuous longitudinal data.Statistics in medicine · 2022Article
- A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus).Genetics · 2016Article
- Quantitative trait locus mapping with background control in genetic populations of clonal F1 and double cross.Journal of integrative plant biology · 2015Article
- Generalized linear model for mapping discrete trait loci implemented with LASSO algorithm.PloS one · 2014Article
- Empirical Bayesian LASSO-logistic regression for multiple binary trait locus mapping.BMC genetics · 2013Article
- An efficient hierarchical generalized linear mixed model for mapping QTL of ordinal traits in crop cultivars.PloS one · 2013Article
- Bayesian mapping of genome-wide epistatic imprinted loci for quantitative traits.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- A new mapping method for quantitative trait loci of silkworm.BMC genetics · 2011Article
- Article
- Statistical analysis of genetic interactions.Genetics research · 2010Review
- Article
- Bayesian model selection for characterizing genomic imprinting effects and patterns.Bioinformatics (Oxford, England) · 2010Article
- Mapping multiple quantitative trait loci under Bayes error control.Genetics research · 2009Article
- Bayesian robust analysis for genetic architecture of quantitative traits.Bioinformatics (Oxford, England) · 2009Article
- A new Bayesian automatic model selection approach for mapping quantitative trait loci under variance component model.Genetica · 2009Article
- Bayesian joint mapping of quantitative trait loci for Gaussian and categorical characters in line crosses.Genetica · 2009Article
- Hierarchical generalized linear models for multiple quantitative trait locus mapping.Genetics · 2009Article
- Bayesian multilocus association mapping on ordinal and censored traits and its application to the analysis of genetic variation among Oryza sativa L. germplasms.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2009Article
- Variable selection for large p small n regression models with incomplete data: mapping QTL with epistases.BMC bioinformatics · 2008Article
- Advances in Bayesian multiple quantitative trait loci mapping in experimental crosses.Heredity · 2008Review
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4 authors.
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Abstract
Development of statistical methods and software for mapping interacting QTL has been the focus of much recent research. We previously developed a Bayesian model selection framework, based on the composite model space approach, for mapping multiple epistatic QTL affecting continuous traits. In this study we extend the composite model space approach to complex ordinal traits in experimental crosses. We jointly model main and epistatic effects of QTL and environmental factors on the basis of the ordinal probit model (also called threshold model) that assumes a latent continuous trait underlies the generation of the ordinal phenotypes through a set of unknown thresholds. A data augmentation approach is developed to jointly generate the latent data and the thresholds. The proposed ordinal probit model, combined with the composite model space framework for continuous traits, offers a convenient way for genomewide interacting QTL analysis of ordinal traits. We illustrate the proposed method by detecting new QTL and epistatic effects for an ordinal trait, dead fetuses, in a F(2) intercross of mice. Utility and flexibility of the method are also demonstrated using a simulated data set. Our method has been implemented in the freely available package R/qtlbim, which greatly facilitates the general usage of the Bayesian methodology for genomewide interacting QTL analysis for continuous, binary, and ordinal traits in experimental crosses.
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