ArticleGenetics2007
Defective decapentaplegic signaling results in heart overgrowth and reduced cardiac output in Drosophila.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- In Vivo Models of Cardiovascular Disease:Biomedicines · 2025Review
- TGF-β Family Signaling inCold Spring Harbor perspectives in biology · 2017Review
- On the Morphology of the Drosophila Heart.Journal of cardiovascular development and disease · 2016Review
- SPARC-Dependent Cardiomyopathy in Drosophila.Circulation. Cardiovascular genetics · 2016Article
- Strategies for exploring TGF-β signaling in Drosophila.Methods (San Diego, Calif.) · 2014Review
- 3D chromatin interactions organize Yan chromatin occupancy and repression at the even-skipped locus.Genes & development · 2013Article
- Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi.Development (Cambridge, England) · 2013Article
- Signal transduction pathways, intrinsic regulators, and the control of cell fate choice.Biochimica et biophysica acta · 2013Review
- Excessive Dpp signaling induces cardial apoptosis through dTAK1 and dJNK during late embryogenesis of Drosophila.Journal of biomedical science · 2011Article
- JAK/Stat signaling regulates heart precursor diversification in Drosophila.Development (Cambridge, England) · 2011Article
- Odd-skipped maintains prohemocyte potency and blocks blood cell development in Drosophila.Genesis (New York, N.Y. : 2000) · 2011Article
- Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila.Developmental cell · 2008Article
- Salmonella pathogenesis reveals that BMP signaling regulates blood cell homeostasis and immune responses in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- A combinatorial enhancer recognized by Mad, TCF and Brinker first activates then represses dpp expression in the posterior spiracles of Drosophila.Developmental biology · 2008Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
During germ-band extension, Decapentaplegic (Dpp) signals from the dorsal ectoderm to maintain Tinman (Tin) expression in the underlying mesoderm. This signal specifies the cardiac field, and homologous genes (BMP2/4 and Nkx2.5) perform this function in mammals. We showed previously that a second Dpp signal from the dorsal ectoderm restricts the number of pericardial cells expressing the transcription factor Zfh1. Here we report that, via Zfh1, the second Dpp signal restricts the number of Odd-skipped-expressing and the number of Tin-expressing pericardial cells. Dpp also represses Tin expression independently of Zfh1, implicating a feed-forward mechanism in the regulation of Tin pericardial cell number. In the adjacent dorsal muscles, Dpp has the opposite effect. Dpp maintains Krüppel and Even-skipped expression required for muscle development. Our data show that Dpp refines the cardiac field by limiting the number of pericardial cells. This maintains the boundary between pericardial and dorsal muscle cells and defines the size of the heart. In the absence of the second Dpp signal, pericardial cells overgrow and this significantly reduces larval cardiac output. Our study suggests the existence of a second round of BMP signaling in mammalian heart development and that perhaps defects in this signal play a role in congenital heart defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.